Plant Name: Cynanchum formosanum
Taxonomic Information:
Plant ID: NPO20274
Plant Latin Name: Cynanchum formosanum
Taxonomy Genus: Cynanchum
Taxonomy Family: Apocynaceae
Plant External Links:
NCBI TaxonomyDB:
1740881
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FFAR1; FFAR4; GPBAR1; | |
| PPARD; PPARA; PPARG; | |
| NR1H4; | |
| ALOX15; HPGD; AKR1B10; | |
| FABP3; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 5.250E-09 | 2.286E-05 | FFAR4, NR1H4, PPARA, PPARD, PPARG |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.782E-08 | 4.311E-05 | NR1H4, PPARA, PPARD, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 3.815E-08 | 7.009E-05 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 6.408E-08 | 9.966E-05 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.317E-07 | 1.593E-04 | FABP3, FFAR1, NR1H4, PPARG |
| MF | Unclassified; | GO:0004872; receptor activity | 6.394E-07 | 4.491E-04 | FFAR1, FFAR4, GPBAR1, HPGD, NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 9.299E-07 | 5.956E-04 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 1.061E-06 | 6.418E-04 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 1.061E-06 | 6.418E-04 | GPBAR1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 2.131E-06 | 1.160E-03 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 3.045E-06 | 1.507E-03 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 3.534E-06 | 1.673E-03 | PPARA, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 5.300E-06 | 2.308E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 5.300E-06 | 2.308E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 5.300E-06 | 2.308E-03 | ALOX15, HPGD |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 5.300E-06 | 2.308E-03 | FABP3, PPARG |
| BP | GO:0023052; signaling | GO:0032024; positive regulation of insulin secretion | 8.974E-06 | 3.689E-03 | FFAR1, NR1H4, PPARD |
| BP | GO:0008152; metabolic process | GO:0071073; positive regulation of phospholipid biosynthetic process | 1.271E-05 | 4.941E-03 | FABP3, NR1H4 |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 1.306E-05 | 4.988E-03 | ALOX15, PPARA, PPARD |
| MF | GO:0060089; molecular transducer activity | GO:0004955; prostaglandin receptor activity | 1.588E-05 | 5.961E-03 | HPGD, PPARG |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 1.940E-05 | 6.705E-03 | PPARA, PPARD |
| BP | GO:0009987; cellular process | GO:0010745; negative regulation of macrophage derived foam cell differentiation | 2.749E-05 | 8.676E-03 | PPARA, PPARG |
| BP | GO:0050896; response to stimulus | GO:0009725; response to hormone | 2.975E-05 | 9.255E-03 | FABP3, FFAR4, HPGD, PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0046321; positive regulation of fatty acid oxidation | 3.206E-05 | 9.697E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0032966; negative regulation of collagen biosynthetic process | 3.206E-05 | 9.697E-03 | PPARD, PPARG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 6.289E-08 | 1.887E-06 | FABP3, PPARG, PPARA, PPARD |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 5.010E-03 | 7.516E-02 | HPGD, PPARG |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 2.274E-02 | 8.529E-02 | PPARG, PPARD |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 1.727E-02 | 8.529E-02 | PPARG |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.727E-02 | 8.529E-02 | ALOX15 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 2.139E-02 | 8.529E-02 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.786E-02 | 8.529E-02 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.904E-02 | 8.529E-02 | AKR1B10 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 5.270E-02 | 9.163E-02 | LMNA |
| 09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 5.498E-02 | 9.163E-02 | PPARG |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
