CMAUP Plant Collective Molecular Activities

Plant Name: Corydalis cava

Taxonomic Information:

Plant ID: NPO2020
Plant Latin Name: Corydalis cava
Taxonomy Genus: Corydalis
Taxonomy Family: Papaveraceae

Plant External Links:

NCBI TaxonomyDB: 581246
Plant-of-the-World-Online: 672129-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Analgesic; Antianxiety; Antidepressant; Antiseptic; Antispasmodic; Antitussive; Cancer; Cardiotonic; Hallucinogenic; Hypotensive; Sedative

Geographical Distribution:

Ukraine; Romania; Belarus; Italy; Portugal; Denmark; Poland; Sweden; France; Switzerland; Austria; Albania; China; Hungary; Belgium; Germany; Russia; Spain; Bulgaria

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA1A; DRD1; DRD2;
Peptide receptor (family A GPCR)	TSHR;
Transcription Factor	HIF1A;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP3A4; CYP1A2; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	ADRA1A	Alpha-1a adrenergic receptor	P35348	CHEMBL229
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.430E-13	1.182E-08	CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.341E-09	3.877E-05	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.193E-08	9.550E-05	CYP1A2, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.193E-08	9.550E-05	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.760E-07	3.305E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	2.351E-07	3.657E-04	CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	3.746E-07	4.798E-04	CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.929E-07	6.795E-04	CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	7.235E-07	7.877E-04	CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	9.160E-07	8.672E-04	CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.447E-06	1.260E-03	CYP1A2, CYP3A4
BP	GO:0007610; behavior	GO:0008542; visual learning	1.707E-06	1.328E-03	DRD1, DRD2, HIF1A
BP	Unclassified;	GO:0021853; cerebral cortex GABAergic interneuron migration	2.410E-06	1.663E-03	DRD1, DRD2
CC	GO:0016020; membrane	GO:0031090; organelle membrane	5.223E-06	2.774E-03	ADRA1A, CYP1A2, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, LMNA
BP	GO:0023052; signaling	GO:0051584; regulation of dopamine uptake involved in synaptic transmission	6.743E-06	3.337E-03	DRD1, DRD2
BP	GO:0032501; multicellular organismal process	GO:0030432; peristalsis	1.083E-05	4.914E-03	DRD1, DRD2
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.083E-05	4.914E-03	CYP1A2, CYP2C19
BP	GO:0032502; developmental process	GO:0021756; striatum development	1.323E-05	5.881E-03	DRD1, DRD2
BP	GO:0007610; behavior	GO:0007625; grooming behavior	1.588E-05	6.402E-03	DRD1, DRD2
MF	GO:0060089; molecular transducer activity	GO:0004952; dopamine neurotransmitter receptor activity	1.588E-05	6.402E-03	DRD1, DRD2
BP	GO:0050896; response to stimulus	GO:0060134; prepulse inhibition	1.876E-05	7.043E-03	DRD1, DRD2
BP	GO:0009987; cellular process	GO:0060158; phospholipase C-activating dopamine receptor signaling pathway	1.876E-05	7.043E-03	DRD1, DRD2
MF	GO:0005488; binding	GO:0035240; dopamine binding	1.876E-05	7.043E-03	DRD1, DRD2
BP	GO:0023052; signaling	GO:0050806; positive regulation of synaptic transmission	2.787E-05	9.335E-03	ADRA1A, DRD1, DRD2
MF	GO:0060089; molecular transducer activity	GO:0004935; adrenergic receptor activity	2.884E-05	9.372E-03	ADRA1A, DRD2
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	5.026E-05	1.372E-02	CYP1A2, CYP2C19, CYP2D6, CYP3A4, DRD1
CC	GO:0043226; organelle	GO:0097730; non-motile cilium	1.187E-04	2.590E-02	DRD1, DRD2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.682E-08	1.180E-06	CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.267E-07	7.187E-06	CYP1A2, CYP3A4, CYP2C19
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7.081E-06	6.871E-05	DRD1, DRD2, ADRA1A, TSHR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.496E-06	6.871E-05	CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.808E-06	6.871E-05	CYP1A2, CYP3A4, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.106E-04	8.110E-04	DRD1, DRD2, TSHR
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	2.613E-04	1.643E-03	DRD1, DRD2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.602E-04	2.250E-03	CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.664E-04	2.015E-03	CYP1A2, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	8.418E-04	3.704E-03	DRD1, DRD2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.358E-03	5.433E-03	CYP2D6, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	1.796E-03	6.585E-03	DRD1, DRD2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05012	Parkinson's disease	2.170E-03	7.345E-03	DRD1, DRD2
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	3.457E-03	9.506E-03	DRD1, ADRA1A
09160 Human Diseases	09164 Substance dependence	hsa05034	Alcoholism	3.419E-03	9.506E-03	DRD1, DRD2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.498E-03	7.850E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2;
NA: NA	False perceptions	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; DRD2;
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2;
NA: NA	Benign prostatic hypertrophy	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	DRD2;
NA: NA	Inflammatory diseases	NA	DRD2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2;
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADRA1A; DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA1A; DRD1; DRD2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1; DRD2;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	DRD2;
NA: NA	Hyperaemia	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2;
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2;
C00-D49: Neoplasms	Breast cancer	C50	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA1A; DRD1; DRD2;
NA: NA	Itching	NA	DRD2;
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2;
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA1A; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2;
N00-N99: Diseases of the genitourinary system	Prostate hyperplasia	N40	ADRA1A;
C00-D49: Neoplasms	Prostate cancer	C61	ADRA1A;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	ADRA1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	ADRA1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	DRD2;
J00-J99: Diseases of the respiratory system	Asthma	J45	DRD2;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1; DRD2;
NA: NA	Vomiting	NA	DRD2;
NA: NA	Schizoaffective disorders	NA	DRD2;
NA: NA	Peripheral vasoconstriction	NA	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Post-traumatic stress disorder	F43.1	ADRA1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	DRD2;
NA: NA	Malignant phaeochromocytoma	NA	DRD2;
NA: NA	Malignant essential hypertension	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; DRD2;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1; DRD2;
N00-N99: Diseases of the genitourinary system	Stress urinary incontinence	N39.3	ADRA1A;
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	ADRA1A; DRD2;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
NA: NA	Corneal vascularity	NA	DRD2;
N00-N99: Diseases of the genitourinary system	Benign prostatic hyperplasia	N40	ADRA1A;
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2;
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ADRA1A;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	DRD2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases