Plant Name: Aristolochia triangularis
Taxonomic Information:
Plant ID: NPO20173
Plant Latin Name: Aristolochia triangularis
Taxonomy Genus: Aristolochia
Taxonomy Family: Aristolochiaceae
Plant External Links:
NCBI TaxonomyDB:
158574
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
ChinaTraditional Medicine System:
TCMGeographical Distribution:
China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HTR2B; | |
| TOP1; | |
| MTOR; | |
| CHEK1; | |
| HIF1A; TP53; | |
| PMP22; GMNN; HBB; THPO; LMNA; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
| Isomerase | TOP1 | DNA topoisomerase I | P11387 | CHEMBL1781 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Protein Kinase | CHEK1 | Serine/threonine-protein kinase Chk1 | O14757 | CHEMBL4630 |
| Small molecule receptor (family A GPCR) | HTR2B | Serotonin 2b (5-HT2b) receptor | P41595 | CHEMBL1833 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | PMP22 | Peripheral myelin protein 22 | Q01453 | CHEMBL1293298 |
| Unclassified | GMNN | Geminin | O75496 | CHEMBL1293278 |
| Unclassified | HBB | Hemoglobin beta chain | P68871 | CHEMBL4331 |
| Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 5.462E-07 | 7.725E-03 | HIF1A, LMNA, MTOR, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.003E-05 | 6.321E-04 | TP53, HIF1A, MTOR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 5.484E-05 | 1.728E-03 | TP53, HIF1A, MTOR |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 2.734E-04 | 5.741E-03 | TP53, HIF1A, MTOR |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 7.927E-04 | 9.374E-03 | TP53, MTOR |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04150 | mTOR signaling pathway | 6.758E-04 | 9.374E-03 | HIF1A, MTOR |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 8.928E-04 | 9.374E-03 | CHEK1, TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| NA: NA | Coronary artery restenosis | NA | MTOR; |
| I00-I99: Diseases of the circulatory system | Coronary heart disease | I25.1 | HTR2B; |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR; |
| C00-D49: Neoplasms | Advanced ovarian cancer | NA | TOP1; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TOP1; TP53; |
| I00-I99: Diseases of the circulatory system | Congestive heart failure | I50 | HTR2B; |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR; |
| C00-D49: Neoplasms | Gastric cancer | C16 | TOP1; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR; |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MTOR; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | CHEK1; MTOR; |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TOP1; |
| A00-B99: Certain infectious and parasitic diseases | Irritable bowel syndrome | A09, K58, K59.1 | HTR2B; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | TOP1; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TOP1; TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TOP1; CHEK1; HIF1A; TP53; MTOR; |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | TOP1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychoses | F20-F29 | HTR2B; |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A; HTR2B; |
| C00-D49: Neoplasms | Breast cancer | C50 | TOP1; |
| C00-D49: Neoplasms | Bladder cancer | C67 | TOP1; MTOR; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | CHEK1; MTOR; |
| A00-B99: Certain infectious and parasitic diseases | Acquired immune deficiency syndrome | B20 | TOP1; |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR; |
| C00-D49: Neoplasms | Esophageal cancer | C15 | TOP1; |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | TOP1; |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | HTR2B; |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | TOP1; |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Beta thalassemia | D56.1 | HBB; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | HTR2B; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CHEK1; HIF1A; MTOR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TOP1; CHEK1; HIF1A; TP53; MTOR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR; |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TOP1; |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | CHEK1; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | MTOR; |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | TOP1; |
| I00-I99: Diseases of the circulatory system | Cerebral infarction | I63 | HTR2B; |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR; |
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
