CMAUP Plant Collective Molecular Activities

Plant Name: Gmelina arborea

Taxonomic Information:

Plant ID: NPO201
Plant Latin Name: Gmelina arborea
Taxonomy Genus: Gmelina
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 201509
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand; China; India

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; TCM; Ayurveda; Siddha

Geographical Distribution:

India; China; Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Peptide receptor (family A GPCR)	OPRD1;
Enzyme_unclassified	TDP1; ALOX15; HPGD;
Protein Kinase	KIT;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Toll-like and Il-1 receptors	TLR2;
Unclassified	LMNA; FABP3; RAB9A; FABP2; FABP4; NPC1; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Kinase	KIT	Stem cell growth factor receptor	P10721	CHEMBL1936
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	8.346E-09	1.514E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015908; fatty acid transport	4.927E-07	4.470E-04	FABP3, PPARA, PPARD, PPARG
MF	Unclassified;	GO:0004872; receptor activity	5.220E-07	4.546E-04	FFAR1, FFAR4, HPGD, KIT, NPC1, OPRD1, PPARA, PPARD, PPARG, TLR2
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	1.008E-06	7.572E-04	FABP3, FFAR1, PPARG, TLR2
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	4.313E-06	2.134E-03	FFAR4, PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0045834; positive regulation of lipid metabolic process	5.635E-06	2.454E-03	FABP3, KIT, PPARA, PPARG
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	9.151E-06	3.496E-03	PPARA, PPARG
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	9.152E-06	3.496E-03	FABP3, PPARA, PPARG, TLR2
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	9.985E-06	3.733E-03	ALOX15, FABP4, FFAR4, KIT, NPC1, OPRD1, PPARD, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	1.372E-05	4.524E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	1.372E-05	4.524E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	1.372E-05	4.524E-03	ALOX15, HPGD
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	1.372E-05	4.524E-03	FABP3, PPARG
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.445E-05	4.524E-03	PPARA, PPARD, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	2.533E-05	7.556E-03	PPARA, PPARD, PPARG
MF	GO:0060089; molecular transducer activity	GO:0004955; prostaglandin receptor activity	4.106E-05	1.132E-02	HPGD, PPARG

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.074E-13	1.265E-11	FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.323E-03	4.035E-02	KIT, PPARD
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.939E-03	8.877E-02	KIT, PPARG, PPARD
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	7.276E-03	8.877E-02	RAB9A, TLR2
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.246E-02	1.266E-01	HPGD, PPARG
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.741E-03	8.877E-02	CYP2A6
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	6.447E-02	1.659E-01	PPARA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6.715E-02	1.659E-01	CYP2A6
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	1.064E-01	1.659E-01	TLR2
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	1.106E-01	1.659E-01	NPC1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases