CMAUP Plant Collective Molecular Activities

Plant Name: Pinus monophylla

Taxonomic Information:

Plant ID: NPO20056
Plant Latin Name: Pinus monophylla
Taxonomy Genus: Pinus
Taxonomy Family: Pinaceae

Plant External Links:

NCBI TaxonomyDB: 151562
Plant-of-the-World-Online: 197026-2

Used in Medicines:

Unknown.

Geographical Distribution:

United States; Mexico

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4; GPBAR1;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	ALOX15; HPGD; AKR1B10;
Unclassified	FABP3; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	5.250E-09	2.286E-05	FFAR4, NR1H4, PPARA, PPARD, PPARG
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.782E-08	4.311E-05	NR1H4, PPARA, PPARD, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	3.815E-08	7.009E-05	NR1H4, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0015908; fatty acid transport	6.408E-08	9.966E-05	FABP3, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	1.317E-07	1.593E-04	FABP3, FFAR1, NR1H4, PPARG
MF	Unclassified;	GO:0004872; receptor activity	6.394E-07	4.491E-04	FFAR1, FFAR4, GPBAR1, HPGD, NR1H4, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	9.299E-07	5.956E-04	NR1H4, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.061E-06	6.418E-04	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.061E-06	6.418E-04	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	2.131E-06	1.160E-03	NR1H4, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	3.045E-06	1.507E-03	NR1H4, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	3.534E-06	1.673E-03	PPARA, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	5.300E-06	2.308E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	5.300E-06	2.308E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	5.300E-06	2.308E-03	ALOX15, HPGD
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	5.300E-06	2.308E-03	FABP3, PPARG
BP	GO:0023052; signaling	GO:0032024; positive regulation of insulin secretion	8.974E-06	3.689E-03	FFAR1, NR1H4, PPARD
BP	GO:0008152; metabolic process	GO:0071073; positive regulation of phospholipid biosynthetic process	1.271E-05	4.941E-03	FABP3, NR1H4
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	1.306E-05	4.988E-03	ALOX15, PPARA, PPARD
MF	GO:0060089; molecular transducer activity	GO:0004955; prostaglandin receptor activity	1.588E-05	5.961E-03	HPGD, PPARG
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	1.940E-05	6.705E-03	PPARA, PPARD
BP	GO:0009987; cellular process	GO:0010745; negative regulation of macrophage derived foam cell differentiation	2.749E-05	8.676E-03	PPARA, PPARG
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	2.975E-05	9.255E-03	FABP3, FFAR4, HPGD, PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0046321; positive regulation of fatty acid oxidation	3.206E-05	9.697E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0032966; negative regulation of collagen biosynthetic process	3.206E-05	9.697E-03	PPARD, PPARG

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.289E-08	1.887E-06	FABP3, PPARG, PPARA, PPARD
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	5.010E-03	7.516E-02	HPGD, PPARG
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.274E-02	8.529E-02	PPARG, PPARD
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.727E-02	8.529E-02	PPARG
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.727E-02	8.529E-02	ALOX15
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.139E-02	8.529E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.786E-02	8.529E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.904E-02	8.529E-02	AKR1B10
09150 Organismal Systems	09152 Endocrine system	hsa04911	Insulin secretion	4.984E-02	9.163E-02	FFAR1
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	4.352E-02	9.163E-02	LMNA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases