CMAUP Plant Collective Molecular Activities

Plant Name: Turpinia ternata

Taxonomic Information:

Plant ID: NPO19984
Plant Latin Name: Turpinia ternata
Taxonomy Genus: Turpinia
Taxonomy Family: Staphyleaceae

Plant External Links:

NCBI TaxonomyDB: 697042
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPL; TDP1; TERT; PGD; POLB;
Miscellaneous ion channel	BCL2;
Lyase	CA2; CA7; CA4; CA12; CA9;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	NFKB1;
DNA methyltransferase	DNMT1;
ATP-binding cassette	ABCB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
DNA methyltransferase	DNMT1	DNA (cytosine-5)-methyltransferase 1	P26358	CHEMBL1993
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.009E-13	8.730E-09	CA12, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.988E-11	3.620E-07	CA12, CA2, CA4, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.432E-10	7.795E-07	CA12, CA2, CA4, CA7, CA9
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	4.532E-08	1.096E-04	ABCB1, CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.091E-06	2.160E-03	CA12, CA2, CA4, CA7, CA9, DNMT1, NR1H4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.688E-06	2.827E-03	CA2, CA7
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	1.688E-06	2.827E-03	BCL2, NR1H4
BP	GO:0009987; cellular process	GO:0051716; cellular response to stimulus	3.432E-06	4.982E-03	ALPL, BCL2, CA2, CA9, DNMT1, NFKB1, NR1H4, POLB, TDP1, TERT

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.937E-13	5.064E-11	CA12, CA2, CA4, CA7, CA9
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.892E-05	6.905E-04	ABCB1, CA2, NR1H4
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	5.717E-05	1.391E-03	DNMT1, ABCB1, BCL2, NFKB1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.316E-04	2.402E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	DNMT1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Tumors	C00-D48	TERT;
C00-D49: Neoplasms	Breast cancer	C50	TERT; CA9; BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	BCL2;
C00-D49: Neoplasms	Prostate cancer	C61	TERT; BCL2;
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9; BCL2;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	DNMT1;
C00-D49: Neoplasms	Liver cancer	C22	TERT;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ABCB1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT; DNMT1;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	DNMT1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT;
C00-D49: Neoplasms	Multiple myeloma	C90	TERT; BCL2;
C00-D49: Neoplasms	Ovarian cancer	C56	TERT; ABCB1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; DNMT1; ABCB1; CA9; BCL2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DNMT1; ABCB1;
C00-D49: Neoplasms	Soft tissue sarcoma	C00-D49	DNMT1;
C00-D49: Neoplasms	Solid tumours	C00-D48	ABCB1; CA9;
C00-D49: Neoplasms	Melanoma	C43	TERT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases