CMAUP Plant Collective Molecular Activities

Plant Name: Schisandra glaucescens

Plant ID: NPO19979
Plant Latin Name: Schisandra glaucescens
Taxonomy Genus: Schisandra
Taxonomy Family: Schisandraceae

NCBI TaxonomyDB: 124787
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK9;
Unclassified	MAPT;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Protein Kinase	MAPK9	c-Jun N-terminal kinase 2	P45984	CHEMBL4179
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0031334; positive regulation of protein complex assembly	1.351E-04	7.271E-01	MAPK9, MAPT
BP	GO:0009987; cellular process	GO:0019896; axonal transport of mitochondrion	9.317E-04	7.271E-01	MAPT
BP	GO:0032501; multicellular organismal process	GO:0048143; astrocyte activation	9.317E-04	7.271E-01	MAPT
MF	GO:0005488; binding	GO:0034452; dynactin binding	1.139E-03	7.739E-01	MAPT
CC	GO:0044464; cell part	GO:0030673; axolemma	1.656E-03	8.772E-01	MAPT
MF	GO:0005488; binding	GO:0034185; apolipoprotein binding	1.656E-03	8.772E-01	MAPT
CC	GO:0044464; cell part	GO:0030425; dendrite	3.428E-02	1.000E+00	MAPT
CC	GO:0043226; organelle	GO:0005874; microtubule	3.906E-02	1.000E+00	MAPT
CC	GO:0044464; cell part	GO:0005737; cytoplasm	4.631E-02	1.000E+00	MAPK9, MAPT
MF	GO:0005488; binding	GO:0019902; phosphatase binding	1.691E-02	1.000E+00	MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.619E-04	7.611E-03	MAPK9, MAPT
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	7.486E-03	1.899E-02	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	8.582E-03	1.899E-02	MAPK9
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.007E-02	1.899E-02	MAPK9
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.087E-02	1.899E-02	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	1.177E-02	1.899E-02	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.326E-02	1.899E-02	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.455E-02	1.899E-02	MAPK9
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	1.415E-02	1.899E-02	MAPK9
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	1.385E-02	1.899E-02	MAPK9

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases