CMAUP Plant Collective Molecular Activities

Plant Name: Curculigo orchioides

Taxonomic Information:

Plant ID: NPO19963
Plant Latin Name: Curculigo orchioides
Taxonomy Genus: Curculigo
Taxonomy Family: Hypoxidaceae

Plant External Links:

NCBI TaxonomyDB: 681286
Plant-of-the-World-Online: 64163-1

Used in Medicines:

Country/Region:

Guinea; Philippines; India; Vietnam; China; Thailand

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM

Geographical Distribution:

Pakistan; Australia; Bangladesh; Myanmar; Guinea; Philippines; Indonesia; India; New Caledonia; Cambodia; Vietnam; China; Laos; Sri Lanka; Japan; Taiwan; Nepal; Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	BLM; HSD17B10; AKR1B1; HPGD; AKR1B10;
Lyase	CA2; CA3; CA1; CA7; CA5A; CA6; CA12; CA14; CA9;
Transcription Factor	HIF1A; NFKB1;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.387E-08	8.683E-05	BLM, CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.054E-06	5.115E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	6.147E-06	8.924E-03	AKR1B1, AKR1B10, HPGD, HSD17B10
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.139E-25	1.772E-20	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.136E-19	1.237E-15	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.820E-18	4.257E-14	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.524E-05	1.844E-02	CA1, CA2
BP	GO:0008152; metabolic process	GO:0044597; daunorubicin metabolic process	2.841E-05	2.812E-02	AKR1B1, AKR1B10
BP	GO:0008152; metabolic process	GO:0044598; doxorubicin metabolic process	2.841E-05	2.812E-02	AKR1B1, AKR1B10
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.575E-05	3.075E-02	CA2, CA9, HPGD, TSHR
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	4.359E-05	3.164E-02	AKR1B1, HIF1A, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.888E-24	2.512E-22	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5.864E-04	1.276E-02	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	4.064E-04	1.276E-02	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4.628E-04	1.276E-02	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.571E-03	2.733E-02	AKR1B10, AKR1B1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.265E-03	3.285E-02	CA2, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	4.698E-03	5.838E-02	HIF1A, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	8.511E-03	9.256E-02	LMNA, NFKB1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.207E-02	1.166E-01	MAPT, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.376E-02	1.197E-01	HPGD, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases