CMAUP Plant Collective Molecular Activities

Plant Name: Penstemon gentianoides

Taxonomic Information:

Plant ID: NPO1996
Plant Latin Name: Penstemon gentianoides
Taxonomy Genus: Penstemon
Taxonomy Family: Plantaginaceae

Plant External Links:

NCBI TaxonomyDB: 388147
Plant-of-the-World-Online: 808108-1

Used in Medicines:

Country/Region:

Mexico

Traditional Medicine System:

Geographical Distribution:

Guatemala; Honduras; Mexico

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	OPRD1; NPSR1;
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A; ADRA2B;
Hydrolase	ACHE;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA7; CA4;
Oxidoreductase	TYR;
Enzyme_unclassified	ALOX12; HSD17B2; HSD17B10; NOX4; POLB;
Transcription Factor	AHR;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	3.381E-09	3.681E-05	ADRA2A, ADRA2B, ADRA2C
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.375E-09	4.053E-05	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	7.445E-09	4.053E-05	CYP1A1, CYP1A2, CYP1B1, CYP2D6, NOX4
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	1.351E-08	4.215E-05	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	1.351E-08	4.215E-05	ADRA2A, ADRA2B, ADRA2C
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.100E-08	6.377E-05	CYP1A1, CYP1A2, CYP1B1, CYP2D6
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	1.883E-07	1.709E-04	ADRA2A, ADRA2B, ADRA2C
MF	GO:0005488; binding	GO:0051379; epinephrine binding	1.883E-07	1.709E-04	ADRA2A, ADRA2B, ADRA2C
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.690E-07	2.249E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.027E-07	2.829E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.145E-07	3.717E-04	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0020037; heme binding	1.474E-06	6.829E-04	CYP1A1, CYP1A2, CYP1B1, CYP2D6, NOX4
BP	GO:0009987; cellular process	GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway	3.786E-06	1.330E-03	ADRA2A, ADRA2B, ADRA2C
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.412E-06	1.479E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0005506; iron ion binding	4.415E-06	1.479E-03	ALOX12, CYP1A1, CYP1A2, CYP1B1, CYP2D6
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	5.408E-06	1.707E-03	AXL, CA2, CDK1, CYP1A1, CYP1A2, CYP1B1, KDR
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	5.863E-06	1.773E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.989E-06	2.002E-03	CA2, CA7
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	1.086E-05	2.543E-03	CA2, CDK1, CYP1A1, CYP1A2, CYP1B1, FLT3, NOX4, TYR
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.185E-05	2.633E-03	AURKB, FLT3, IGF1R, KDR, PIM1
MF	Unclassified;	GO:0004872; receptor activity	1.154E-05	2.633E-03	ADRA2A, ADRA2B, ADRA2C, AHR, AXL, FLT3, IGF1R, KDR, MET, NPSR1, OPRD1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.396E-05	2.981E-03	CYP1A1, CYP1A2
BP	GO:0065007; biological regulation	GO:0032148; activation of protein kinase B activity	1.958E-05	3.876E-03	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0030168; platelet activation	2.434E-05	4.690E-03	ADRA2A, ADRA2B, ADRA2C, AXL
BP	GO:0032502; developmental process	GO:0007568; aging	2.615E-05	4.909E-03	AURKB, CDK1, CYP1A1, NOX4, POLB
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	3.208E-05	5.773E-03	ADRA2A, ADRA2B, ADRA2C, AXL, FLT3, IGF1R, KDR, MET, NPSR1, OPRD1
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.484E-05	6.219E-03	CYP1A2, CYP2D6
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	3.559E-05	6.301E-03	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, PIM1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	3.603E-05	6.304E-03	CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B2
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	4.873E-05	7.880E-03	CYP1A2, CYP2D6
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	4.873E-05	7.880E-03	CYP1A1, CYP2D6
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	4.873E-05	7.880E-03	FLT3, KDR
BP	GO:0065007; biological regulation	GO:0043406; positive regulation of MAP kinase activity	4.947E-05	7.921E-03	ADRA2A, ADRA2B, CDK1, FLT3, NOX4
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	5.169E-05	8.215E-03	ADRA2A, ALOX12, IGF1R, KDR, MET, NOX4
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	6.492E-05	9.880E-03	CYP1A1, CYP1A2
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	6.619E-05	9.940E-03	ADRA2A, AXL, CYP1A1, CYP1B1, FLT3, IGF1R, KDR, NOX4, OPRD1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	9.655E-09	7.145E-07	CA12, CA2, CA4, CA7
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	9.027E-07	3.340E-05	HSD17B2, CYP1A1, CYP1B1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.649E-06	4.068E-05	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.165E-06	7.706E-05	CYP2D6, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.898E-05	4.289E-04	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.085E-04	1.338E-03	OPRD1, ADRA2C, ADRA2B, ADRA2A
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.490E-04	2.632E-03	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7.430E-04	6.109E-03	OPRD1, ADRA2C, ADRA2B, ADRA2A
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.396E-04	4.992E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3; ACHE;
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1;
NA: NA	GIST	NA	FLT3;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRD1;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADRA2B;
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1; TYR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1; ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1;
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; ADRA2C;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE; ADRA2A; ADRA2C; OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1;
NA: NA	Acute nonspecific diarrhea	NA	OPRD1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE; ADRA2C;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; ADRA2C;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2B; ADRA2C; OPRD1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE; OPRD1;
C00-D49: Neoplasms	CLL	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; ADRA2C;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; CA2;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	HIV infections	NA	AHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases