CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPR35;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	RECQL; TDP1; BLM; GLO1; HPGD; AKR1B10; ALOX12; HSD17B1; AKR1B1; HSD17B10; NOX4; APEX1; POLB;
Hydrolase	ACHE;
Protein Phosphatase	CDC25B;
Isomerase	TOP2A;
Protein Kinase	TEK; MET; INSR; AXL; SRC; FLT3; CDK1; EGFR; PIM1; AURKB; NUAK1; KDR; IGF1R; CSNK2A1;
Lyase	CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Lysine demethylase	KDM4E;
Serine protease	F10; F2;
Aspartic protease	BACE1;
Metallo protease	MMP12;
Transcription Factor	HIF1A;
Transferase	FUT7;
SLC superfamily of solute carriers	SLC22A6;
Unclassified	SMAD3; LMNA; FABP5; HSPA1A;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392

Showing 1 to 10 of 55 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	1.088E-08	4.084E-06	AXL, EGFR, F10, INSR, MET, NOX4, SRC, TEK
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	2.176E-07	4.738E-05	EGFR, IGF1R, INSR, KDR, SRC
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	6.250E-07	1.106E-04	ESR1, ESR2, NR1H4, PIM1, PPARA, RORC, SRC
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	6.624E-07	1.127E-04	CYP1A1, HIF1A, LMNA, NOX4, PPARA, SMAD3, SRC, TEK
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	8.188E-07	1.351E-04	AKR1B1, APEX1, AXL, CDK1, CYP1B1
BP	GO:0048511; rhythmic process	GO:0048511; rhythmic process	1.324E-06	2.017E-04	AXL, CSNK2A1, EGFR, ESR1, PPARA, RORC, SRC, TOP2A
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	1.831E-06	2.694E-04	ESR1, ESR2, NR1H4, PPARA, RORC, SRC
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	2.462E-06	3.330E-04	AXL, CDK1, CSNK2A1, EGFR, FLT3
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	6.095E-06	7.253E-04	CDK1, ESR1, ESR2, NR1H4, PPARA, RORC
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	6.177E-06	7.310E-04	AKR1B1, AKR1B10, CYP1A1, CYP1B1, ESR1, HSD17B1, NR1H4

Showing 1 to 10 of 60 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.455E-04	5.066E-03	HSD17B1, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.302E-05	2.116E-04	CA12, CA4, CA7
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.739E-06	5.653E-05	SRC, INSR, KDR, TEK, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	9.315E-06	1.730E-04	INSR, TEK, HIF1A, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	3.646E-05	4.740E-04	INSR, KDR, TEK, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	3.372E-04	3.653E-03	INSR, KDR, TEK, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	4.902E-04	4.902E-03	SMAD3, INSR, EGFR, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.250E-09	1.625E-07	SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	6.726E-06	1.663E-04	SMAD3, SRC, KDR, MET, EGFR, HSPA1A, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	2.309E-04	2.729E-03	SRC, KDR, MET, EGFR, IGF1R

Showing 1 to 10 of 21 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR; EGFR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Crepis foetida

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities