CMAUP Plant Collective Molecular Activities

Plant Name: Doronicum grandiflorum

Plant ID: NPO19888
Plant Latin Name: Doronicum grandiflorum
Taxonomy Genus: Doronicum
Taxonomy Family: Asteraceae

NCBI TaxonomyDB: 118763
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Unclassified	NPC1; MAPT;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0046686; response to cadmium ion	2.472E-05	5.383E-01	CYP1A2, NPC1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	4.845E-04	9.220E-01	CYP1A2, NPC1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.212E-04	9.220E-01	CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.212E-04	9.220E-01	CYP1A2
CC	GO:0044464; cell part	GO:0030673; axolemma	2.483E-03	1.000E+00	MAPT
CC	GO:0044464; cell part	GO:0036464; cytoplasmic ribonucleoprotein granule	2.846E-02	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0020037; heme binding	1.975E-02	1.000E+00	CYP1A2
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.465E-02	1.000E+00	CYP1A2
MF	GO:0005488; binding	GO:0019902; phosphatase binding	2.526E-02	1.000E+00	MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	7.498E-04	8.998E-03	CYP1A2
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.988E-03	1.838E-02	CYP1A2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.344E-03	1.838E-02	CYP1A2
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.675E-03	1.838E-02	CYP1A2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.719E-03	1.838E-02	CYP1A2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.031E-02	1.838E-02	CYP1A2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.091E-02	1.838E-02	CYP1A2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.225E-02	1.838E-02	CYP1A2
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	1.834E-02	2.445E-02	NPC1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	2.499E-02	2.999E-02	MAPT

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases