Plant Name: Arabidopsis thaliana
Taxonomic Information:
Plant ID: NPO19866
Plant Latin Name: Arabidopsis thaliana
Taxonomy Genus: Arabidopsis
Taxonomy Family: Brassicaceae
Plant External Links:
NCBI TaxonomyDB:
3702
Plant-of-the-World-Online:
277970-1
Used in Medicines:
Country/Region:
IndiaTraditional Medicine System:
Indian FolkMedicinal Functions:
Mouthwash
Geographical Distribution:
Turkey; Italy; Kenya; Sudan; Mongolia; France; Ethiopia; Rwanda; Tanzania; Somalia; Ireland; Argentina; Norway; Uzbekistan; Belarus; Algeria; Cape Verde; China; Belgium; Germany; Kazakhstan; Djibouti; Spain; Ukraine; Eritrea; Netherlands; Libya; Denmark; Poland; Finland; United States; Morocco; Sweden; Japan; Switzerland; New Zealand; Russia; Bulgaria; Romania; Albania; Portugal; South Africa; Tunisia; Tajikistan; India; United Kingdom; Austria; Uganda; Greece; Hungary; Cyprus
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ADRA2B; P2RY2; P2RY6; P2RY14; | |
| TSHR; | |
| TDP1; | |
| TP53; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Small molecule receptor (family A GPCR) | ADRA2B | Alpha-2b adrenergic receptor | P18089 | CHEMBL1942 |
| Small molecule receptor (family A GPCR) | P2RY2 | Purinergic receptor P2Y2 | P41231 | CHEMBL4398 |
| Small molecule receptor (family A GPCR) | P2RY6 | Pyrimidinergic receptor P2Y6 | Q15077 | CHEMBL4714 |
| Small molecule receptor (family A GPCR) | P2RY14 | Purinergic receptor P2Y14 | Q15391 | CHEMBL4518 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| CC | GO:0044425; membrane part | GO:0005887; integral component of plasma membrane | 9.528E-05 | 1.153E-01 | ADRA2B, P2RY14, P2RY2, P2RY6, TSHR |
| BP | GO:0009987; cellular process | GO:0007189; adenylate cyclase-activating G-protein coupled receptor signaling pathway | 3.781E-04 | 3.006E-01 | ADRA2B, TSHR |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 2.486E-03 | 7.315E-01 | P2RY6, TSHR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 2.661E-08 | 1.224E-06 | P2RY6, P2RY14, P2RY2, ADRA2B, TSHR |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.325E-03 | 3.048E-02 | LMNA, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 2.571E-02 | 7.075E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05217 | Basal cell carcinoma | 2.179E-02 | 7.075E-02 | TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 2.219E-02 | 7.075E-02 | TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 2.454E-02 | 7.075E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 2.610E-02 | 7.075E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 2.649E-02 | 7.075E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 2.805E-02 | 7.075E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 2.883E-02 | 7.075E-02 | TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | ADRA2B; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | ADRA2B; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
