CMAUP Plant Collective Molecular Activities

Plant Name: Tilia miqueliana

Taxonomic Information:

Plant ID: NPO1982
Plant Latin Name: Tilia miqueliana
Taxonomy Genus: Tilia
Taxonomy Family: Malvaceae

Plant External Links:

NCBI TaxonomyDB: 332109
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA2; CA7; CA4; CA12;
Oxidoreductase	TYR;
Enzyme_unclassified	HSD17B2;
Transcription Factor	AHR;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.930E-11	1.073E-06	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.116E-09	2.304E-05	CA12, CA2, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.868E-09	2.650E-05	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.197E-08	3.794E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.322E-07	2.880E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.760E-07	2.948E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.760E-07	2.948E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.235E-07	9.267E-04	CA2, CA7
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.447E-06	1.500E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.402E-06	1.500E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	6.743E-06	5.873E-03	CYP1A1, CYP1A2
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	1.083E-05	9.071E-03	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.476E-11	1.420E-09	CA12, CA2, CA4, CA7
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.320E-08	1.254E-07	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	8.807E-07	5.578E-06	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.743E-06	8.277E-06	HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.496E-06	2.089E-05	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.808E-06	2.472E-05	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.602E-04	1.093E-03	CYP1A2, CYP1A1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.661E-05	1.537E-04	CA2, CA4
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.276E-03	4.746E-03	HSD17B2, CYP1A2, CYP1A1, TYR
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.498E-03	4.746E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	HIV infections	NA	AHR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Melanoma	C43	TYR;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases