CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	HKDC1; USP2;
Oxidoreductase	MAOB;
Unclassified	MAPT; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	HKDC1	Putative hexokinase HKDC1	Q2TB90	CHEMBL1741200
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Showing 1 to 6 of 6 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0048699; generation of neurons	2.483E-03	1.000E+00	MAPT
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.483E-03	1.000E+00	MAOB
BP	GO:0009987; cellular process	GO:1990000; amyloid fibril formation	2.483E-03	1.000E+00	MAPT
BP	GO:0008152; metabolic process	GO:0042420; dopamine catabolic process	2.483E-03	1.000E+00	MAOB
BP	GO:0009987; cellular process	GO:0019896; axonal transport of mitochondrion	2.793E-03	1.000E+00	MAPT
BP	GO:0032501; multicellular organismal process	GO:0048143; astrocyte activation	2.793E-03	1.000E+00	MAPT
BP	GO:0008152; metabolic process	GO:0032930; positive regulation of superoxide anion generation	4.341E-03	1.000E+00	MAPT
BP	GO:0009987; cellular process	GO:0071404; cellular response to low-density lipoprotein particle stimulus	4.341E-03	1.000E+00	NPC1
BP	Unclassified;	GO:2000188; regulation of cholesterol homeostasis	4.341E-03	1.000E+00	NPC1
BP	GO:0002376; immune system process	GO:0001774; microglial cell activation	5.270E-03	1.000E+00	MAPT

Showing 1 to 10 of 43 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00524	Butirosin and neomycin biosynthesis	1.499E-03	3.307E-02	HKDC1
09100 Metabolism	09105 Amino acid metabolism	hsa00340	Histidine metabolism	7.179E-03	3.307E-02	MAOB
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	5.090E-03	3.307E-02	MAOB
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	1.046E-02	3.307E-02	MAOB
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.194E-02	3.307E-02	MAOB
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	8.967E-03	3.307E-02	HKDC1
09100 Metabolism	09105 Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1.194E-02	3.307E-02	MAOB
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9.563E-03	3.307E-02	HKDC1
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	1.343E-02	3.307E-02	HKDC1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	1.432E-02	3.307E-02	HKDC1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Maytenus emarginata

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities