CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	EIF4A1;
Transcription Factor	RELA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	EIF4A1	Eukaryotic initiation factor 4A-I	P60842	CHEMBL2052028
Transcription Factor	RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	CHEMBL5533

Showing 1 to 2 of 2 entries

Previous1Next

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0033590; response to cobalamin	3.106E-04	1.000E+00	RELA
BP	GO:0008152; metabolic process	GO:2000630; positive regulation of miRNA metabolic process	5.177E-04	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:0071316; cellular response to nicotine	8.282E-04	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:0071354; cellular response to interleukin-6	1.553E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0010224; response to UV-B	1.863E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0035994; response to muscle stretch	1.966E-03	1.000E+00	RELA
BP	GO:0008152; metabolic process	GO:0031293; membrane protein intracellular domain proteolysis	1.966E-03	1.000E+00	RELA
BP	GO:0008152; metabolic process	GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter	2.277E-03	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:1901522; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	2.897E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0046627; negative regulation of insulin receptor signaling pathway	3.104E-03	1.000E+00	RELA

Showing 1 to 10 of 38 entries

Previous1 2 3 4Next

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	5.692E-03	1.944E-02	RELA
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	6.390E-03	1.944E-02	RELA
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	9.378E-03	1.944E-02	RELA
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	5.692E-03	1.944E-02	RELA
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	4.894E-03	1.944E-02	RELA
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	5.493E-03	1.944E-02	RELA
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	6.490E-03	1.944E-02	RELA
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	6.589E-03	1.944E-02	RELA
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6.789E-03	1.944E-02	RELA
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	7.486E-03	1.944E-02	RELA

Showing 1 to 10 of 10 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Duguetia chrysocarpa

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities