CMAUP Plant Collective Molecular Activities

Plant Name: Michelia alba

Taxonomic Information:

Plant ID: NPO19592
Plant Latin Name: Michelia alba
Taxonomy Genus: Michelia
Taxonomy Family: Magnoliaceae

Plant External Links:

NCBI TaxonomyDB: 114509
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Hydrolase	ACHE;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Enzyme_unclassified	ALOX15; HPGD;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	NFKB1;
Unclassified	FABP3; LMNA; FABP2; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP2D6; CYP2A6; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	8.346E-09	1.069E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.611E-08	1.948E-05	CYP2C19, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.043E-08	3.155E-05	CYP2A6, CYP2C19, CYP2C9, CYP2D6
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	7.455E-08	6.493E-05	FFAR4, NFKB1, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.765E-07	1.325E-04	CYP2A6, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.878E-07	2.815E-04	ALOX15, CYP2A6, CYP2C19, CYP2C9, CYP2D6
BP	GO:0051179; localization	GO:0015908; fatty acid transport	4.927E-07	3.155E-04	FABP3, PPARA, PPARD, PPARG
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	5.439E-07	3.201E-04	CYP2A6, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	1.008E-06	5.244E-04	FABP3, FFAR1, PPARG, TLR2
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.061E-06	5.374E-04	CYP2A6, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	3.298E-06	1.330E-03	CYP2A6, CYP2C19, CYP2C9, CYP2D6, PPARD
MF	GO:0005488; binding	GO:0020037; heme binding	6.601E-06	2.282E-03	CYP2A6, CYP2C19, CYP2C9, CYP2D6
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	9.151E-06	2.807E-03	PPARA, PPARG
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	9.152E-06	2.807E-03	FABP3, PPARA, PPARG, TLR2
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.115E-05	3.373E-03	CYP2C19, CYP2C9, CYP2D6
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	1.372E-05	3.879E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	1.372E-05	3.879E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	1.372E-05	3.879E-03	ALOX15, HPGD
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	1.372E-05	3.879E-03	FABP3, PPARG
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.445E-05	3.932E-03	PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	1.919E-05	5.097E-03	CYP2A6, CYP2D6
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	2.533E-05	6.567E-03	PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.106E-05	9.824E-03	CYP2C19, CYP2C9
MF	GO:0060089; molecular transducer activity	GO:0004955; prostaglandin receptor activity	4.106E-05	9.824E-03	HPGD, PPARG

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.074E-13	1.659E-11	FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.835E-07	1.934E-05	CYP2C9, CYP2A6, CYP2D6, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.385E-06	6.770E-05	CYP2C9, CYP2D6, ALOX15, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.615E-06	6.770E-05	CYP2C9, ALOX15, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.653E-05	4.245E-04	CYP2C9, ALOX15, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.335E-05	5.780E-04	CYP2C9, CYP2A6, CYP2D6
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	6.139E-05	7.016E-04	CYP2C9, CYP2A6, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.247E-04	6.247E-03	HPGD, PPARG, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.323E-03	1.058E-02	NFKB1, PPARD
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.232E-03	1.058E-02	NFKB1, TLR2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases