CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 1 group H	NR1H3; NR1H2;
SLC superfamily of solute carriers	SLCO1B3;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 1 group H	NR1H3	LXR-alpha	Q13133	CHEMBL2808
Nuclear hormone receptor subfamily 1 group H	NR1H2	LXR-beta	P55055	CHEMBL4093
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	2.412E-07	1.050E-03	NR1H2, NR1H3
BP	GO:0009987; cellular process	GO:0060336; negative regulation of interferon-gamma-mediated signaling pathway	2.412E-07	1.050E-03	NR1H2, NR1H3
BP	GO:0009987; cellular process	GO:0010745; negative regulation of macrophage derived foam cell differentiation	1.254E-06	2.275E-03	NR1H2, NR1H3
BP	Unclassified;	GO:2000188; regulation of cholesterol homeostasis	1.463E-06	2.275E-03	NR1H2, NR1H3
CC	GO:0032991; macromolecular complex	GO:0090575; RNA polymerase II transcription factor complex	2.021E-02	1.000E+00	NR1H3
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.861E-02	1.000E+00	SLCO1B3
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	4.918E-02	1.000E+00	NR1H3
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.888E-05	1.111E-02	NR1H2, NR1H3
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	2.746E-05	1.424E-02	NR1H2, NR1H3

Showing 1 to 9 of 9 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.031E-02	1.769E-02	NR1H3
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.061E-02	1.769E-02	SLCO1B3
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	8.798E-05	4.399E-04	NR1H2, NR1H3
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	2.248E-02	2.248E-02	NR1H3
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.982E-02	2.248E-02	NR1H3

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Marchantia polymorpha

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities