Plant Name: Marchantia polymorpha
Taxonomic Information:
Plant ID: NPO19581
Plant Latin Name: Marchantia polymorpha
Taxonomy Genus: Marchantia
Taxonomy Family: Marchantiaceae
Plant External Links:
NCBI TaxonomyDB:
3197
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| NR1H3; NR1H2; | |
| SLCO1B3; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group H | NR1H3 | LXR-alpha | Q13133 | CHEMBL2808 |
| Nuclear hormone receptor subfamily 1 group H | NR1H2 | LXR-beta | P55055 | CHEMBL4093 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 2.412E-07 | 1.050E-03 | NR1H2, NR1H3 |
| BP | GO:0009987; cellular process | GO:0060336; negative regulation of interferon-gamma-mediated signaling pathway | 2.412E-07 | 1.050E-03 | NR1H2, NR1H3 |
| BP | GO:0009987; cellular process | GO:0010745; negative regulation of macrophage derived foam cell differentiation | 1.254E-06 | 2.275E-03 | NR1H2, NR1H3 |
| BP | Unclassified; | GO:2000188; regulation of cholesterol homeostasis | 1.463E-06 | 2.275E-03 | NR1H2, NR1H3 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.888E-05 | 1.111E-02 | NR1H2, NR1H3 |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 2.746E-05 | 1.424E-02 | NR1H2, NR1H3 |
| CC | GO:0032991; macromolecular complex | GO:0090575; RNA polymerase II transcription factor complex | 2.021E-02 | 1.000E+00 | NR1H3 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 2.861E-02 | 1.000E+00 | SLCO1B3 |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 4.918E-02 | 1.000E+00 | NR1H3 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 8.798E-05 | 4.399E-04 | NR1H2, NR1H3 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.031E-02 | 1.769E-02 | NR1H3 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 1.769E-02 | SLCO1B3 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 2.248E-02 | 2.248E-02 | NR1H3 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 1.982E-02 | 2.248E-02 | NR1H3 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
