CMAUP Plant Collective Molecular Activities

Plant Name: Millettia pinnata

Taxonomic Information:

Plant ID: NPO19432
Plant Latin Name: Millettia pinnata
Taxonomy Genus: Millettia
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 56065
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Philippines; Indonesia; India

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Ayurveda; Siddha

Geographical Distribution:

Philippines; Indonesia; India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Enzyme_unclassified	TDP1;
Lyase	CA2; CA12; CA1; CA9; CA5B; CA5A; CA3; CA14; CA7; CA4; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Toll-like and Il-1 receptors	TLR2;
Unclassified	HTT; LMNA; FABP3; FABP5; FABP2; FABP4; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.923E-12	4.654E-09	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.278E-08	2.611E-05	FABP2, FABP3, FABP4, FABP5
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.742E-31	2.121E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	3.219E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.376E-24	5.853E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.465E-22	1.342E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.213E-05	1.417E-02	CA1, CA2
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	2.991E-05	1.809E-02	ESR2, PPARA, PPARD
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	6.618E-05	3.792E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.016E-30	2.828E-28	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.730E-10	4.066E-09	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.438E-04	5.387E-03	CA2, CA4
09160 Human Diseases	09162 Immune diseases	hsa05323	Rheumatoid arthritis	1.026E-01	2.064E-01	TLR2
09150 Organismal Systems	09152 Endocrine system	hsa04922	Glucagon signaling pathway	1.145E-01	2.064E-01	PPARA
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	1.134E-01	2.064E-01	TLR2
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	1.091E-01	2.064E-01	CA2
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	1.198E-01	2.064E-01	TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	1.177E-01	2.064E-01	TLR2
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.230E-01	2.064E-01	PPARA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Edema	NA	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases