Plant Name: Trigonostemon howii
Taxonomic Information:
Plant ID: NPO19424
Plant Latin Name: Trigonostemon howii
Taxonomy Genus: Trigonostemon
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Protein Kinase | PRKCE | Protein kinase C epsilon | Q02156 | CHEMBL3582 |
| Protein Kinase | PRKCB | Protein kinase C beta | P05771 | CHEMBL3045 |
| Protein Kinase | PRKCG | Protein kinase C gamma | P05129 | CHEMBL2938 |
| Protein Kinase | PRKCD | Protein kinase C delta | Q05655 | CHEMBL2996 |
| Protein Kinase | PRKCA | Protein kinase C alpha | P17252 | CHEMBL299 |
| Protein Kinase | PRKCQ | Protein kinase C theta | Q04759 | CHEMBL3920 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 3.547E-13 | 2.574E-09 | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ |
| MF | GO:0003824; catalytic activity | GO:0004698; calcium-dependent protein kinase C activity | 6.660E-11 | 2.901E-07 | PRKCA, PRKCB, PRKCG |
| BP | GO:0009987; cellular process | GO:0090330; regulation of platelet aggregation | 1.357E-08 | 2.110E-05 | PRKCA, PRKCD, PRKCQ |
| BP | GO:0050896; response to stimulus | GO:0046627; negative regulation of insulin receptor signaling pathway | 6.740E-08 | 6.989E-05 | PRKCB, PRKCD, PRKCQ |
| BP | GO:0008152; metabolic process | GO:0035408; histone H3-T6 phosphorylation | 8.041E-08 | 7.170E-05 | PRKCA, PRKCB |
| MF | GO:0003824; catalytic activity | GO:0035403; histone kinase activity (H3-T6 specific) | 8.041E-08 | 7.170E-05 | PRKCA, PRKCB |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 1.980E-07 | 1.597E-04 | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ |
| BP | GO:0009987; cellular process | GO:0035556; intracellular signal transduction | 2.457E-07 | 1.726E-04 | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ |
| MF | GO:0003824; catalytic activity | GO:0004699; calcium-independent protein kinase C activity | 2.412E-07 | 1.726E-04 | PRKCD, PRKCE |
| BP | GO:0009987; cellular process | GO:0002429; immune response-activating cell surface receptor signaling pathway | 2.144E-06 | 8.906E-04 | PRKCB, PRKCD, PRKCE, PRKCQ |
| BP | GO:0009987; cellular process | GO:0034351; negative regulation of glial cell apoptotic process | 2.250E-06 | 8.906E-04 | PRKCA, PRKCD |
| CC | GO:0044464; cell part | GO:0048471; perinuclear region of cytoplasm | 1.773E-05 | 5.515E-03 | PRKCA, PRKCD, PRKCE, PRKCG |
| BP | GO:0008152; metabolic process | GO:0050996; positive regulation of lipid catabolic process | 1.852E-05 | 5.681E-03 | PRKCD, PRKCE |
| BP | GO:0022610; biological adhesion | GO:0030155; regulation of cell adhesion | 2.036E-05 | 6.156E-03 | PRKCA, PRKCD, PRKCE, PRKCQ |
| BP | GO:0008152; metabolic process | GO:0051054; positive regulation of DNA metabolic process | 2.580E-05 | 7.697E-03 | PRKCD, PRKCG, PRKCQ |
| CC | GO:0016020; membrane | GO:0005886; plasma membrane | 1.397E-04 | 3.012E-02 | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 2.466E-04 | 4.838E-02 | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCQ |
| CC | GO:0044464; cell part | GO:0005783; endoplasmic reticulum | 2.082E-03 | 1.946E-01 | PRKCA, PRKCD, PRKCE |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.185E-14 | 8.533E-13 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, PRKCQ |
| 09150 Organismal Systems | 09153 Circulatory system | hsa04270 | Vascular smooth muscle contraction | 4.112E-14 | 1.480E-12 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, PRKCQ |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04530 | Tight junction | 1.011E-13 | 2.426E-12 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, PRKCQ |
| 09150 Organismal Systems | 09151 Immune system | hsa04666 | Fc gamma R-mediated phagocytosis | 1.166E-11 | 2.098E-10 | PRKCG, PRKCB, PRKCE, PRKCD, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04925 | Aldosterone synthesis and secretion | 3.722E-09 | 5.359E-08 | PRKCG, PRKCB, PRKCE, PRKCA |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 9.118E-09 | 1.094E-07 | PRKCB, PRKCE, PRKCD, PRKCA |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 1.242E-08 | 1.277E-07 | PRKCB, PRKCE, PRKCD, PRKCQ |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.832E-08 | 1.649E-07 | PRKCG, PRKCB, PRKCE, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 4.134E-07 | 2.480E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09155 Excretory system | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 2.421E-07 | 1.584E-06 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05143 | African trypanosomiasis | 9.784E-08 | 7.827E-07 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09155 Excretory system | hsa04960 | Aldosterone-regulated sodium reabsorption | 1.366E-07 | 9.832E-07 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 6.507E-07 | 2.704E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04730 | Long-term depression | 5.101E-07 | 2.575E-06 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04150 | mTOR signaling pathway | 5.101E-07 | 2.575E-06 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 5.364E-07 | 2.575E-06 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 6.984E-07 | 2.704E-06 | PRKCG, PRKCB, PRKCE, PRKCA |
| 09160 Human Diseases | 09164 Substance dependence | hsa05031 | Amphetamine addiction | 7.135E-07 | 2.704E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04720 | Long-term potentiation | 6.816E-07 | 2.704E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04971 | Gastric acid secretion | 9.648E-07 | 3.308E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 8.509E-07 | 3.063E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04911 | Insulin secretion | 1.468E-06 | 4.640E-06 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04012 | ErbB signaling pathway | 1.575E-06 | 4.640E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 1.805E-06 | 4.640E-06 | PRKCB, PRKCD, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04727 | GABAergic synapse | 1.631E-06 | 4.640E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04970 | Salivary secretion | 1.687E-06 | 4.640E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09159 Environmental adaptation | hsa04713 | Circadian entrainment | 2.055E-06 | 5.087E-06 | PRKCG, PRKCB, PRKCA |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04540 | Gap junction | 1.631E-06 | 4.640E-06 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09164 Substance dependence | hsa05032 | Morphine addiction | 1.805E-06 | 4.640E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04916 | Melanogenesis | 2.399E-06 | 5.087E-06 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04070 | Phosphatidylinositol signaling system | 2.257E-06 | 5.087E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 3.287E-06 | 6.397E-06 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05231 | Choline metabolism in cancer | 2.473E-06 | 5.087E-06 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05146 | Amoebiasis | 2.399E-06 | 5.087E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04723 | Retrograde endocannabinoid signaling | 2.473E-06 | 5.087E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04972 | Pancreatic secretion | 2.121E-06 | 5.087E-06 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 2.623E-06 | 5.247E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04724 | Glutamatergic synapse | 3.563E-06 | 6.577E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 3.378E-06 | 6.400E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 3.953E-06 | 6.941E-06 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04728 | Dopaminergic synapse | 5.169E-06 | 8.862E-06 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 7.500E-06 | 1.200E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09151 Immune system | hsa04650 | Natural killer cell mediated cytotoxicity | 5.927E-06 | 9.924E-06 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04310 | Wnt signaling pathway | 6.900E-06 | 1.129E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04921 | Oxytocin signaling pathway | 9.508E-06 | 1.488E-05 | PRKCG, PRKCB, PRKCA |
| 09150 Organismal Systems | 09151 Immune system | hsa04670 | Leukocyte transendothelial migration | 3.953E-06 | 6.941E-06 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04020 | Calcium signaling pathway | 1.406E-05 | 2.153E-05 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 2.015E-05 | 2.961E-05 | PRKCG, PRKCB, PRKCA |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04510 | Focal adhesion | 1.985E-05 | 2.961E-05 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 2.262E-05 | 3.257E-05 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 2.814E-05 | 3.973E-05 | PRKCG, PRKCB, PRKCA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 3.982E-05 | 5.514E-05 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.485E-04 | 1.980E-04 | PRKCG, PRKCB, PRKCA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 1.116E-03 | 1.435E-03 | PRKCB, PRKCA |
| 09150 Organismal Systems | 09151 Immune system | hsa04062 | Chemokine signaling pathway | 1.273E-03 | 1.607E-03 | PRKCB, PRKCD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 3.170E-04 | 4.150E-04 | PRKCB, PRKCQ |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04930 | Type II diabetes mellitus | 8.409E-05 | 1.142E-04 | PRKCE, PRKCD |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| I00-I99: Diseases of the circulatory system | Ischemic reperfusion injury | I00-I99 | PRKCE; |
| I00-I99: Diseases of the circulatory system | Acute myocardial infarction | I21-I22 | PRKCD; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Renal transplantation | D89.8 | PRKCB; |
| NA: NA | Reperfusion injury and heart attacks | NA | PRKCD; |
| C00-D49: Neoplasms | Central nervous system tumors | NA | PRKCB; |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | PRKCB; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | PRKCB; |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | PRKCE; |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | PRKCB; |
| C00-D49: Neoplasms | Cancer | C00-C96 | PRKCB; |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | PRKCB; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
