CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Enzyme_unclassified	TDP1;
Lyase	CA2; CA1; CA12; CA9; CA13; CA7; CA5A; CA3; CA14; CA5B; CA4; CA6;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Transcription Factor	NFKB1;
Unclassified	HTT; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP2A6; CYP2D6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594

Showing 1 to 10 of 23 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.942E-08	4.271E-05	CYP2C19, CYP2C9, CYP2D6
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.222E-07	3.340E-04	CYP2A6, CYP2C19, CYP2C9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.996E-27	5.439E-23	CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.295E-25	1.250E-21	CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.934E-06	1.504E-03	CYP2A6, CYP2C19, CYP2C9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.066E-06	3.053E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	9.152E-06	5.694E-03	CYP2A6, CYP2C19, CYP2C9, CYP2D6, NPC1
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.516E-11	4.981E-08	CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	6.917E-08	9.413E-05	CYP2A6, CYP2C19, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	9.919E-07	8.000E-04	CYP2A6, CYP2C19, CYP2C9

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	9.792E-34	7.148E-32	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14, CA13
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.093E-06	3.990E-05	CYP2C9, CYP2A6, CYP2D6, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.840E-05	1.908E-03	CYP2C9, CYP2A6, CYP2D6
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.294E-03	2.042E-02	CYP2C9, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.040E-04	5.256E-03	CYP2C9, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.518E-03	2.042E-02	CYP2C9, CYP2A6
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.790E-04	3.837E-03	CYP2C9, CYP2D6, CYP2C19
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.154E-04	3.837E-03	CA2, CA4
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	3.079E-03	2.248E-02	NFKB1, ESR2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.109E-04	2.024E-03	CYP2C9, CYP2A6, CYP2C19

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Edema	NA	CA2;

Showing 1 to 6 of 6 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Roemeria refracta

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities