CMAUP Plant Collective Molecular Activities

Plant Name: Thespesia populnea

Taxonomic Information:

Plant ID: NPO19367
Plant Latin Name: Thespesia populnea
Taxonomy Genus: Thespesia
Taxonomy Family: Malvaceae

Plant External Links:

NCBI TaxonomyDB: 3638
Plant-of-the-World-Online: 564713-1

Used in Medicines:

Country/Region:

Philippines; India

Traditional Medicine System:

Geographical Distribution:

Bangladesh; Liberia; Sudan; Guinea; Cambodia; Bahamas; Netherlands; Somalia; Vanuatu; Nigeria; Cameroon; Burkina Faso; Benin; Ghana; Cuba; Venezuela; Cape Verde; Togo; China; Oman; Haiti; Belize; Tanzania; Eritrea; Maldives; Gambia; Philippines; New Caledonia; Mauritius; Trinidad and Tobago; Vietnam; Dominican Republic; Jamaica; Seychelles; Honduras; Mexico; India; Senegal; Mozambique; Colombia; Sri Lanka; Kenya; Taiwan; Fiji

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Miscellaneous ion channel	BCL2; BCL2L1;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Enzyme_unclassified	ALOX15; HSD17B10; LDHA; LDHB; ALOX12; AKR1B1; POLB;
Lysine demethylase	KDM4E;
Transcription Factor	HIF1A;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	MCL1; MPG; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	LDHA	L-lactate dehydrogenase A chain	P00338	CHEMBL4835
Enzyme_unclassified	LDHB	L-lactate dehydrogenase B chain	P07195	CHEMBL4940
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Miscellaneous ion channel	BCL2L1	Apoptosis regulator Bcl-X	Q07817	CHEMBL4625
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	MPG	DNA-3-methyladenine glycosylase	P29372	CHEMBL3396943
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0051434; BH3 domain binding	8.058E-09	1.755E-04	BCL2, BCL2L1, MCL1
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	5.911E-08	4.198E-04	AKR1B1, ALOX12, ALOX15, CYP2C19, GAA, HSD17B10, KDM4E, LDHA, LDHB
BP	GO:0008152; metabolic process	GO:0006089; lactate metabolic process	1.325E-07	4.808E-04	HIF1A, LDHA, LDHB
BP	GO:0009987; cellular process	GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage	5.231E-07	1.424E-03	BCL2, BCL2L1, MCL1, POLB
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	9.167E-07	1.663E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	9.167E-07	1.663E-03	ALOX12, ALOX15
BP	GO:0009987; cellular process	GO:2001243; negative regulation of intrinsic apoptotic signaling pathway	2.011E-06	3.128E-03	BCL2, BCL2L1, HIF1A, MCL1
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	2.748E-06	3.559E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	2.748E-06	3.559E-03	ALOX12, ALOX15
BP	GO:0009987; cellular process	GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	4.736E-06	4.465E-03	BCL2, BCL2L1, MCL1
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	9.151E-06	6.227E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004459; L-lactate dehydrogenase activity	9.151E-06	6.227E-03	LDHA, LDHB
CC	GO:0032991; macromolecular complex	GO:0097136; Bcl-2 family protein complex	1.372E-05	7.297E-03	BCL2L1, MCL1
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	1.939E-05	8.983E-03	ALOX12, ALOX15, CYP2C19
BP	GO:0050896; response to stimulus	GO:0010332; response to gamma radiation	1.939E-05	8.983E-03	BCL2, BCL2L1, POLB
BP	GO:0009987; cellular process	GO:2001244; positive regulation of intrinsic apoptotic signaling pathway	2.164E-05	9.425E-03	BCL2, BCL2L1, MCL1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
Unclassified	Unclassified	hsa01100	Metabolic pathways	8.661E-06	2.685E-04	LDHB, LDHA, GAA, ALOX15, AKR1B1, ALOX12, CYP2C19, HSD17B10
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	8.216E-06	2.685E-04	LMNA, BCL2, BCL2L1, MCL1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.653E-05	5.484E-04	ALOX15, ALOX12, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.211E-04	1.876E-03	LDHA, BCL2, HIF1A
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.552E-04	1.924E-03	ALOX15, ALOX12, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	4.271E-04	2.750E-03	BCL2, BCL2L1, MCL1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.419E-04	2.750E-03	ALOX15, CYP2C19
09100 Metabolism	09101 Carbohydrate metabolism	hsa00640	Propanoate metabolism	4.170E-04	2.750E-03	LDHB, LDHA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	3.661E-04	2.750E-03	GAA, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6.527E-04	3.679E-03	LDHB, LDHA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1.822E-03	7.532E-03	LDHB, LDHA
09100 Metabolism	09105 Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8.261E-04	4.268E-03	LDHB, LDHA
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	1.060E-03	5.057E-03	BCL2, BCL2L1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.822E-03	7.532E-03	LDHA, HIF1A
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	4.436E-04	2.750E-03	POLB, MPG
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.043E-03	7.918E-03	SLCO1B1, SLCO1B3

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Relapsed or refractory chronic lymphocytic leukemia	NA	BCL2L1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
C00-D49: Neoplasms	Solid tumours	C00-D48	BCL2L1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	BCL2;
C00-D49: Neoplasms	Prostate cancer	C61	BCL2;
NA: NA	Lymphoid malignancies	NA	BCL2L1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
C00-D49: Neoplasms	Breast cancer	C50	BCL2;
C00-D49: Neoplasms	Advanced small cell lung cancer	NA	BCL2L1;
C00-D49: Neoplasms	Cancer	C00-C96	BCL2L1; BCL2;
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2;
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases