CMAUP Plant Collective Molecular Activities

Plant Name: Sophora flavescens

Taxonomic Information:

Plant ID: NPO19231
Plant Latin Name: Sophora flavescens
Taxonomy Genus: Sophora
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 49840
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea; China

Traditional Medicine System:

TCM; Kampo

Medicinal Functions:

Anthelmintic; Antibacterial; Antifungal; Antipruritic; Astringent; Bitter; Carminative; Diuretic; Febrifuge; Parasiticide; Parasiticide; Pectoral; Stomachic; Tonic

Geographical Distribution:

South Korea; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Hydrolase	ACHE;
Enzyme_unclassified	TDP1; BLM; MIF; ALOX12; HSD17B1; HSD17B10; NOX4; ALOX15; ALDH1A1; AOX1; POLB; AKR1C3;
Protein Kinase	AURKB; MET; AXL; FLT3; CDK1; EGFR; MAPK1; PIM1; KDR; IGF1R; CSNK2A1;
Lyase	CA12; CA9; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
Oxidoreductase	PTGS1;
Metallo protease	MMP12;
Transcription Factor	HIF1A;
Unclassified	LMNA; THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	MIF	Macrophage migration inhibitory factor	P14174	CHEMBL2085
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	AKR1C3	Aldo-keto-reductase family 1 member C3	P42330	CHEMBL4681
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	7.468E-10	8.131E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C9, NOX4
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.558E-09	2.142E-06	ALOX12, ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.868E-09	3.243E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	1.487E-08	7.357E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C9, NOX4, PTGS1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.138E-08	1.340E-05	CA12, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.362E-07	4.299E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.009E-07	5.478E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	7.044E-07	1.581E-04	AKR1C3, CYP1A2, EGFR, MAPK1
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	7.949E-07	1.714E-04	AXL, CDK1, CSNK2A1, EGFR, FLT3
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	1.186E-06	2.392E-04	AKR1C3, AXL, EGFR, MET, NOX4, THPO
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.308E-06	2.613E-04	CA12, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0042562; hormone binding	1.390E-06	2.752E-04	ACHE, ALDH1A1, EGFR, HSD17B1, IGF1R
MF	GO:0005488; binding	GO:0005496; steroid binding	1.473E-06	2.865E-04	ESR1, ESR2, ESRRA, ESRRB, HSD17B1
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	2.405E-06	4.477E-04	ACHE, AKR1C3, ALDH1A1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C9, EGFR
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.974E-06	5.308E-04	CA12, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	5.071E-06	7.722E-04	ALOX12, ALOX15
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	5.071E-06	7.722E-04	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	5.071E-06	7.722E-04	ALOX12, ALOX15
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	5.331E-06	8.062E-04	ALOX15, EGFR, KDR, MIF, NOX4, THPO
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	6.070E-06	8.754E-04	ALOX12, EGFR, HIF1A, IGF1R, KDR, MAPK1, MET, NOX4
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.114E-05	1.462E-03	BLM, CA12, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP12
BP	GO:0022414; reproductive process	GO:0001892; embryonic placenta development	1.224E-05	1.586E-03	EGFR, ESRRB, HIF1A
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.519E-05	1.901E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.519E-05	1.901E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.892E-05	2.312E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0065007; biological regulation	GO:0043406; positive regulation of MAP kinase activity	2.812E-05	3.156E-03	CDK1, EGFR, FLT3, MAPK1, MIF, NOX4
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.034E-05	3.337E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	3.034E-05	3.337E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.034E-05	3.337E-03	CYP1A2, CYP2C9
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	3.064E-05	3.353E-03	CDK1, ESR1, ESR2, ESRRA, ESRRB
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	3.982E-05	4.090E-03	AKR1C3, CYP1B1, EGFR, HIF1A, NOX4
BP	GO:0008152; metabolic process	GO:0042572; retinol metabolic process	4.289E-05	4.304E-03	AKR1C3, ALDH1A1, CYP1B1
MF	GO:0005488; binding	GO:0042802; identical protein binding	4.517E-05	4.491E-03	ACHE, AOX1, BLM, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MAPK1, MET, MIF
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	4.702E-05	4.654E-03	ESR1, ESR2, ESRRA, ESRRB, PIM1
BP	GO:0008152; metabolic process	GO:0061370; testosterone biosynthetic process	5.049E-05	4.865E-03	AKR1C3, CYP19A1
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	5.049E-05	4.865E-03	ALOX12, ALOX15
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	5.236E-05	4.979E-03	ACHE, ALOX15, CDK1, CYP1A1, EGFR
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	5.223E-05	4.979E-03	CSNK2A1, HIF1A, KDR
MF	GO:0005488; binding	GO:0044877; macromolecular complex binding	6.026E-05	5.583E-03	ACHE, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, PIM1, TSHR
BP	GO:0008152; metabolic process	GO:1903580; positive regulation of ATP metabolic process	6.281E-05	5.771E-03	CDK1, ESRRB, HIF1A
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	6.281E-05	5.771E-03	CYP19A1, CYP1A1, CYP2C9
BP	GO:0009987; cellular process	GO:0014066; regulation of phosphatidylinositol 3-kinase signaling	6.954E-05	6.362E-03	EGFR, FLT3, KDR, MAPK1
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	7.563E-05	6.833E-03	CYP1A2, CYP2C9
MF	GO:0005488; binding	GO:0005524; ATP binding	8.046E-05	7.147E-03	AURKB, AXL, BLM, CDK1, CSNK2A1, EGFR, FLT3, IGF1R, KDR, MAPK1, MET, PIM1
BP	GO:0032501; multicellular organismal process	GO:0007435; salivary gland morphogenesis	1.057E-04	8.787E-03	EGFR, POLB
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	1.056E-04	8.787E-03	AOX1, CYP19A1, CYP1A2, NOX4
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	1.057E-04	8.787E-03	FLT3, KDR
MF	GO:0098772; molecular function regulator	GO:0030235; nitric-oxide synthase regulator activity	1.057E-04	8.787E-03	EGFR, ESR1
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	1.057E-04	8.787E-03	AKR1C3, ALDH1A1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.175E-09	1.634E-07	HSD17B1, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.955E-09	2.054E-07	HSD17B1, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	2.790E-07	7.064E-06	KDR, MAPK1, HIF1A, ESR1, MET, EGFR, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.403E-07	7.064E-06	CYP2C9, ALOX15, AKR1C3, ALOX12, PTGS1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.053E-07	7.064E-06	CYP2C9, CYP1A2, ALDH1A1, CYP1A1, AOX1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.558E-07	7.064E-06	FLT3, MAPK1, MET, HIF1A, EGFR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	5.867E-07	1.019E-05	CSNK2A1, MAPK1, MET, EGFR, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.748E-08	2.200E-06	CA12, CA4, CA7, CA9
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.757E-06	2.714E-05	CYP1A2, CYP1A1, AOX1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.001E-05	1.265E-04	CYP2C9, HSD17B1, CYP1A2, ALOX15, ALDH1A1, AKR1C3, CYP1A1, AOX1, ALOX12, CYP19A1, HSD17B10, PTGS1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.593E-06	6.384E-05	CYP2C9, ALOX15, MAPK1, ALOX12, PTGS1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.778E-05	2.059E-04	MAPK1, MET, EGFR, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.985E-05	2.123E-04	CYP2C9, CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	6.587E-05	5.722E-04	MAPK1, ESR1, EGFR, ESR2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	7.887E-05	6.090E-04	KDR, MAPK1, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	9.686E-05	7.086E-04	KDR, MAPK1, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.365E-04	9.484E-04	KDR, MAPK1, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.145E-05	3.122E-04	CYP2C9, CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	7.687E-05	6.090E-04	MAPK1, HIF1A, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.197E-04	1.454E-03	FLT3, MAPK1, HIF1A, MET, EGFR, IGF1R
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	2.800E-04	1.692E-03	THPO, FLT3, KDR, MET, EGFR
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	4.719E-04	2.430E-03	PIM1, CYP1B1, MAPK1, MET, EGFR
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	3.945E-04	2.285E-03	MAPK1, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.675E-04	1.690E-03	FLT3, PIM1, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	8.805E-04	4.221E-03	KDR, MAPK1, MET, EGFR, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.488E-05	3.232E-04	CYP2C9, CYP1A2, ALOX15
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	4.127E-04	2.294E-03	MAPK1, MET, HIF1A
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	5.329E-04	2.646E-03	MAPK1, ESR1, ESR2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.703E-04	2.430E-03	CYP2C9, CYP1A2, AOX1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	9.887E-04	4.433E-03	MAPK1, EGFR, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.306E-03	5.673E-03	CDK1, MAPK1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	1.424E-03	6.000E-03	MAPK1, HIF1A, EGFR
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	2.484E-03	9.396E-03	KDR, MET, EGFR, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	9.568E-04	4.433E-03	CDK1, MAPK1, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.223E-03	8.829E-03	MAPK1, ESR1, HIF1A
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	2.501E-03	9.396E-03	CDK1, MAPK1, IGF1R
Unclassified	Unclassified	hsa04320	Dorso-ventral axis formation	1.603E-03	6.554E-03	MAPK1, EGFR
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	2.688E-03	9.831E-03	AOX1, MIF

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	ESR1; PIM1; MET; CDK1; IGF1R; KDR; CSNK2A1; FLT3; ACHE; HIF1A; MAPK1; EGFR; CA9;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12; MIF; PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; HIF1A; MAPK1; EGFR; CA9;
NA: NA	Miosis during ocular surgery	NA	PTGS1;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	CLL	NA	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	ESRRA;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1; PTGS1;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; EGFR; PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1;
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12; ESRRA;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ESRRA; PTGS1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; EGFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR; EGFR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; EGFR;
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1;
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1;
NA: NA	Postmenopausal disorder	NA	ESR1;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1;
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	ESRRA; EGFR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1;
NA: NA	Menopausal disorder	NA	ESR1;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; EGFR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR; EGFR;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
NA: NA	GIST	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR;
H00-H59: Diseases of the eye and adnexa	Choroidal neovascularisation	H35	ESRRA;
NA: NA	Gonorrheal vaginitis	NA	ESR1;
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
NA: NA	Rheumatold arthritis	NA	PTGS1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; EGFR; CA9;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1;
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1; FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	ESRRA;
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1; MIF;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; EGFR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1;
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR;
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR; EGFR;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1; FLT3; EGFR; AKR1C3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; EGFR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; EGFR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1; NPSR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ESRRA;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; IGF1R;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR;
C00-D49: Neoplasms	Bladder cancer	C67	EGFR; CYP19A1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1; ESRRA; PTGS1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	ESRRA;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ESRRA;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1; CDK1; IGF1R; ACHE; PTGS1;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; CDK1; IGF1R; KDR; FLT3; EGFR; CYP19A1; CA9;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1; EGFR;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ESRRA;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	ESRRA;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Refractory autoimmune diseases	D84.9, M35.9	MIF;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; EGFR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1;
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases