Plant Name: Erica arborea
Taxonomic Information:
Plant ID: NPO1919
Plant Latin Name: Erica arborea
Taxonomy Genus: Erica
Taxonomy Family: Ericaceae
Plant External Links:
NCBI TaxonomyDB:
270431
Plant-of-the-World-Online:
328204-1
Used in Medicines:
Country/Region:
Turkey; China; ItalyTraditional Medicine System:
TCMGeographical Distribution:
Turkey; Italy; Sudan; France; Ethiopia; Rwanda; Somalia; Saudi Arabia; Algeria; China; Spain; Eritrea; Tanzania; Morocco; New Zealand; Yemen; Russia; Bulgaria; Albania; Portugal; Chad; Tunisia; United Kingdom; Uganda; Greece; Kenya
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TDP1; ALPL; RECQL; P4HB; HSD17B10; HPGD; ALDH1A1; AKR1B1; | |
| GAA; | |
| FYN; EGFR; | |
| CA2; CA1; CA6; | |
| NFKB1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | P4HB | Protein disulfide-isomerase | P07237 | CHEMBL5422 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Protein Kinase | FYN | Tyrosine-protein kinase FYN | P06241 | CHEMBL1841 |
| Protein Kinase | EGFR | Epidermal growth factor receptor erbB1 | P00533 | CHEMBL203 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0009725; response to hormone | 2.669E-07 | 2.906E-03 | AKR1B1, ALPL, CA2, EGFR, FYN, HPGD, NFKB1 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.714E-07 | 2.906E-03 | CA1, CA2, CA6 |
| MF | GO:0003824; catalytic activity | GO:0003824; catalytic activity | 6.983E-07 | 5.069E-03 | AKR1B1, ALDH1A1, ALPL, CA1, CA2, CA6, EGFR, FYN, GAA, HPGD, HSD17B10, P4HB, RECQL, TDP1 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.664E-06 | 1.160E-02 | CA1, CA2, CA6 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 4.923E-06 | 1.531E-02 | CA1, CA2, CA6 |
| BP | GO:0050896; response to stimulus | GO:0009636; response to toxic substance | 9.629E-06 | 1.760E-02 | AKR1B1, ALPL, FYN, HPGD, NFKB1 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 8.428E-06 | 1.760E-02 | CA1, CA2 |
| CC | GO:0043226; organelle | GO:0031982; vesicle | 9.256E-06 | 1.760E-02 | AKR1B1, ALDH1A1, ALPL, CA1, CA2, CA6, EGFR, FYN, GAA, HPGD, P4HB |
| BP | GO:0008283; cell proliferation | GO:0048661; positive regulation of smooth muscle cell proliferation | 2.574E-05 | 4.004E-02 | AKR1B1, EGFR, HPGD |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 2.306E-07 | 2.329E-05 | CA1, CA2, CA6 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 2.256E-04 | 1.139E-02 | GAA, AKR1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 1.095E-03 | 2.710E-02 | EGFR, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.162E-03 | 2.710E-02 | EGFR, NFKB1 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.610E-03 | 2.710E-02 | GAA, ALDH1A1, AKR1B1, ALPL, HSD17B10 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.375E-03 | 2.710E-02 | FYN, EGFR |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.980E-03 | 2.857E-02 | EGFR, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 2.640E-03 | 3.019E-02 | EGFR, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 2.691E-03 | 3.019E-02 | FYN, NFKB1 |
| 09150 Organismal Systems | 09158 Development | hsa04380 | Osteoclast differentiation | 4.291E-03 | 3.533E-02 | FYN, NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
| NA: NA | Edema | NA | CA2; |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2; |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2; |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
