CMAUP Plant Collective Molecular Activities

Plant Name: Magnolia kobus

Taxonomic Information:

Plant ID: NPO1918
Plant Latin Name: Magnolia kobus
Taxonomy Genus: Magnolia
Taxonomy Family: Magnoliaceae

Plant External Links:

NCBI TaxonomyDB: 54732
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Protein Kinase	MAPK1;
Enzyme_unclassified	ALOX15; ALDH1A1;
Metallo protease	MMP3;
Transcription Factor	TP53;
Unclassified	MAPT; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Metallo protease	MMP3	Matrix metalloproteinase 3	P08254	CHEMBL283
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0031334; positive regulation of protein complex assembly	2.158E-06	4.698E-02	ALOX15, MAPT, MMP3, TP53
BP	GO:0050896; response to stimulus	GO:0034614; cellular response to reactive oxygen species	1.393E-05	8.530E-02	MAPK1, MMP3, TP53
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	1.667E-05	8.530E-02	ALOX15, LMNA, MAPK1, MAPT, MMP3, TP53
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	3.700E-05	8.579E-02	ALOX15, MAPK1, MMP3, TP53
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	7.249E-05	9.285E-02	MAPT, TP53
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	4.200E-04	2.029E-01	MAPK1, MAPT
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	9.317E-04	2.568E-01	TSHR
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	9.317E-04	2.568E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	1.397E-03	3.105E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.397E-03	3.105E-01	ALOX15
CC	GO:0043226; organelle	GO:0016604; nuclear body	3.575E-03	4.972E-01	LMNA, MAPT, TP53
CC	GO:0044464; cell part	GO:0030424; axon	5.969E-03	5.962E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0030673; axolemma	7.432E-03	6.321E-01	MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.734E-05	3.035E-03	LMNA, MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	7.262E-05	4.031E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.626E-04	4.304E-03	MAPK1, MAPT, TP53
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.463E-04	4.304E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	2.737E-04	4.304E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	2.359E-04	4.304E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	3.690E-04	4.304E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	3.357E-04	4.304E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	3.804E-04	4.304E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	4.402E-04	4.304E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.920E-04	4.304E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	4.653E-04	4.304E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	6.907E-04	5.898E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.052E-03	7.710E-03	MMP3, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.091E-03	7.710E-03	ALOX15, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.209E-03	7.710E-03	MAPK1, TP53
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	1.250E-03	7.710E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.250E-03	7.710E-03	MAPK1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.533E-03	8.953E-03	MAPK1, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; TP53;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP3;
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	MMP3;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
A00-B99: Certain infectious and parasitic diseases	HCV infection	B17.1, B18.2	MMP3;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
I00-I99: Diseases of the circulatory system	Ischemic stroke	I61-I63	MMP3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
H00-H59: Diseases of the eye and adnexa	Corneal ulcers	H16.0	MMP3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP3;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases