CMAUP Plant Collective Molecular Activities

Plant Name: Helianthus niveus

Taxonomic Information:

Plant ID: NPO19166
Plant Latin Name: Helianthus niveus
Taxonomy Genus: Helianthus
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 73301
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	UBE2N;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP19A1; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	UBE2N	Ubiquitin-conjugating enzyme E2 N	P61088	CHEMBL6089
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.352E-07	5.120E-03	CYP19A1, CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.205E-06	1.312E-02	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.614E-06	1.968E-02	CYP1A2, CYP2C19
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	5.300E-06	2.033E-02	CYP1A2, CYP2C19
MF	GO:0005488; binding	GO:0020037; heme binding	5.603E-06	2.033E-02	CYP19A1, CYP1A2, CYP2C19
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.095E-05	2.650E-02	CYP19A1, CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.684E-05	3.667E-02	CYP1A2, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.028E-05	4.015E-02	CYP19A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	2.605E-05	4.363E-02	CYP19A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	4.491E-05	6.520E-02	CYP19A1, CYP2C19
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.939E-03	7.965E-01	CYP19A1, CYP1A2, CYP2C19
CC	GO:0016020; membrane	GO:0031090; organelle membrane	3.989E-02	1.000E+00	CYP1A2, CYP2C19, LMNA
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	4.289E-02	1.000E+00	CYP19A1, CYP1A2, CYP2C19, LMNA, UBE2N
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	4.958E-02	1.000E+00	LMNA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.034E-05	6.675E-04	CYP1A2, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.744E-04	1.279E-03	CYP1A2, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.231E-04	1.279E-03	CYP1A2, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.464E-04	1.355E-03	CYP1A2, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.116E-03	1.509E-02	CYP1A2, CYP2C19, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.194E-02	3.226E-02	CYP1A2
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.491E-02	3.226E-02	CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.668E-02	3.226E-02	TSHR
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	1.580E-02	3.226E-02	TSHR
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.499E-03	6.597E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases