Plant ID: NPO19123
Plant Latin Name: Polygonatum zanlanscianense
Taxonomy Genus: Polygonatum
Taxonomy Family: Asparagaceae
NCBI TaxonomyDB:
261427
Plant-of-the-World-Online:
540257-1
China
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 8.041E-08 | 1.751E-03 | APEX1, POLB |
BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.205E-06 | 6.562E-03 | CYP2C19, CYP2D6 |
MF | Unclassified; | GO:0003906; DNA-(apurinic or apyrimidinic site) lyase activity | 6.262E-06 | 2.727E-02 | APEX1, POLB |
MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 4.491E-05 | 1.397E-01 | CYP2C19, CYP2D6 |
MF | GO:0005488; binding | GO:0019825; oxygen binding | 7.913E-05 | 2.154E-01 | CYP2C19, CYP2D6 |
BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 1.142E-04 | 2.764E-01 | CYP2C19, CYP2D6 |
BP | GO:0008152; metabolic process | GO:0070988; demethylation | 1.365E-04 | 2.972E-01 | APEX1, CYP2D6 |
BP | GO:0009987; cellular process | GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage | 1.815E-04 | 3.221E-01 | MCL1, POLB |
MF | GO:0005488; binding | GO:0003684; damaged DNA binding | 1.762E-04 | 3.221E-01 | APEX1, POLB |
MF | GO:0005488; binding | GO:0020037; heme binding | 6.423E-04 | 3.996E-01 | CYP2C19, CYP2D6 |
CC | GO:0032991; macromolecular complex | GO:0097136; Bcl-2 family protein complex | 1.863E-03 | 6.053E-01 | MCL1 |
CC | GO:0044464; cell part | GO:0005783; endoplasmic reticulum | 2.082E-03 | 6.225E-01 | APEX1, CYP2D6, HTT |
CC | GO:0016020; membrane | GO:0031090; organelle membrane | 4.614E-03 | 9.554E-01 | CYP2C19, CYP2D6, HTT, MCL1 |
CC | GO:0044464; cell part | GO:0005739; mitochondrion | 5.122E-03 | 9.807E-01 | APEX1, CYP2D6, MCL1 |
CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 6.849E-03 | 1.000E+00 | APEX1, HTT, MCL1, POLB |
CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 2.997E-02 | 1.000E+00 | CYP2C19, CYP2D6 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 3.944E-05 | 5.916E-04 | POLB, APEX1 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.744E-04 | 1.308E-03 | CYP2D6, CYP2C19 |
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 4.594E-04 | 2.297E-03 | CYP2D6, CYP2C19 |
09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.846E-02 | 5.218E-02 | CYP2C19 |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 8.670E-03 | 3.251E-02 | CYP2C19 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.170E-02 | 5.218E-02 | CYP2D6 |
09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 4.128E-02 | 7.739E-02 | MCL1 |
09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 2.435E-02 | 5.218E-02 | CYP2C19 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 4.648E-02 | 7.747E-02 | MCL1 |
09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 5.653E-02 | 8.175E-02 | HTT |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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