Plant Name: Ladeania juncea
Taxonomic Information:
Plant ID: NPO18938
Plant Latin Name: Ladeania juncea
Taxonomy Genus: Ladeania
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
458384
Plant-of-the-World-Online:
60453290-2
Used in Medicines:
Unknown.
Geographical Distribution:
United States
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PPARA; PPARD; | |
| TLR2; | |
| ABCB1; | |
| FABP3; LMNA; FABP2; FABP4; FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 2.737E-10 | 1.986E-06 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 3.301E-06 | 4.492E-03 | FABP3, PPARA, PPARD |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 3.775E-06 | 4.637E-03 | LMNA, PPARA, PPARD, TLR2 |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 1.059E-05 | 1.003E-02 | FABP3, PPARD |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 2.244E-04 | 1.265E-01 | PPARA, PPARD |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 3.257E-04 | 1.509E-01 | PPARA, PPARD |
| CC | Unclassified; | GO:0106003; amyloid-beta complex | 5.115E-03 | 5.682E-01 | TLR2 |
| CC | GO:0044464; cell part | GO:0009986; cell surface | 2.483E-02 | 1.000E+00 | ABCB1, TLR2 |
| CC | GO:0044421; extracellular region part | GO:0070062; extracellular exosome | 3.059E-02 | 1.000E+00 | ABCB1, FABP3, FABP4, FABP5 |
| CC | GO:0044464; cell part | GO:0035578; azurophil granule lumen | 4.162E-02 | 1.000E+00 | FABP5 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.125E-13 | 3.936E-12 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09150 Organismal Systems | 09154 Digestive system | hsa04975 | Fat digestion and absorption | 1.830E-02 | 8.401E-02 | FABP2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05144 | Malaria | 2.184E-02 | 8.401E-02 | TLR2 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 3.674E-02 | 8.401E-02 | LMNA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04922 | Glucagon signaling pathway | 4.455E-02 | 8.401E-02 | PPARA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05146 | Amoebiasis | 4.412E-02 | 8.401E-02 | TLR2 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05323 | Rheumatoid arthritis | 3.979E-02 | 8.401E-02 | TLR2 |
| 09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 4.671E-02 | 8.401E-02 | TLR2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 4.585E-02 | 8.401E-02 | TLR2 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 4.800E-02 | 8.401E-02 | PPARA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
