CMAUP Plant Collective Molecular Activities

Plant Name: Berberis thunbergii

Taxonomic Information:

Plant ID: NPO18832
Plant Latin Name: Berberis thunbergii
Taxonomy Genus: Berberis
Taxonomy Family: Berberidaceae

Plant External Links:

NCBI TaxonomyDB: 121720
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Anthelmintic; Antibacterial; Antiseptic; Cancer; Febrifuge

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Enzyme_unclassified	USP2;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	7.764E-04	8.669E-01	CYP3A4
BP	GO:0008152; metabolic process	GO:0000023; maltose metabolic process	7.764E-04	8.669E-01	GAA
BP	GO:0007610; behavior	GO:0007626; locomotory behavior	8.385E-04	8.669E-01	GAA, USP2
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	7.764E-04	8.669E-01	CYP3A4
MF	GO:0003824; catalytic activity	GO:0032450; maltose alpha-glucosidase activity	7.764E-04	8.669E-01	GAA
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.035E-03	8.669E-01	CYP3A4
MF	GO:0003824; catalytic activity	GO:0004558; alpha-1,4-glucosidase activity	1.035E-03	8.669E-01	GAA
CC	GO:0016020; membrane	GO:0031090; organelle membrane	2.225E-02	1.000E+00	CYP3A4, GAA, LMNA
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	4.149E-02	1.000E+00	LMNA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.230E-03	2.744E-02	CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1.392E-02	2.744E-02	GAA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.145E-02	2.744E-02	CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	7.478E-03	2.744E-02	GAA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.713E-02	2.744E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.812E-02	2.744E-02	CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.763E-02	2.744E-02	CYP3A4
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.837E-02	2.744E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	2.058E-02	2.744E-02	LMNA
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.033E-02	2.744E-02	CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases