Plant ID: NPO18830
Plant Latin Name: Valeriana cardamines
Taxonomy Genus: Valeriana
Taxonomy Family: Caprifoliaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
NR1H4; | |
ELANE; | |
MAPT; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Serine protease | ELANE | Leukocyte elastase | P08246 | CHEMBL248 |
Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0032501; multicellular organismal process | GO:0032682; negative regulation of chemokine production | 2.459E-06 | 5.355E-02 | ELANE, NR1H4 |
BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 1.050E-04 | 1.353E-01 | ELANE, NR1H4 |
MF | GO:0140110; transcription regulator activity | GO:0001076; transcription factor activity, RNA polymerase II transcription factor binding | 1.909E-04 | 1.485E-01 | ELANE, NR1H4 |
MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 4.659E-04 | 2.359E-01 | NR1H4 |
MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.087E-03 | 3.242E-01 | NR1H4 |
MF | GO:0005488; binding | GO:0034452; dynactin binding | 1.708E-03 | 3.610E-01 | MAPT |
MF | GO:0005488; binding | GO:0046965; retinoid X receptor binding | 2.328E-03 | 4.121E-01 | NR1H4 |
CC | GO:0044464; cell part | GO:0030673; axolemma | 2.483E-03 | 4.191E-01 | MAPT |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 3.345E-02 | NR1H4 |
09160 Human Diseases | 09162 Immune diseases | hsa05322 | Systemic lupus erythematosus | 2.011E-02 | 3.345E-02 | ELANE |
09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.499E-02 | 3.345E-02 | MAPT |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 3.777E-02 | 3.777E-02 | MAPT |
09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 2.676E-02 | 3.345E-02 | ELANE |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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