CMAUP Plant Collective Molecular Activities

Plant Name: Magnolia biondii

Taxonomic Information:

Plant ID: NPO18811
Plant Latin Name: Magnolia biondii
Taxonomy Genus: Magnolia
Taxonomy Family: Magnoliaceae

Plant External Links:

NCBI TaxonomyDB: 86725
Plant-of-the-World-Online: 554647-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; CNR2;
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	GAA;
Protein Kinase	MAPK1;
Enzyme_unclassified	ALOX15; ALDH1A1;
Metallo protease	MMP3;
Unclassified	MAPT; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Metallo protease	MMP3	Matrix metalloproteinase 3	P08254	CHEMBL283
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	1.254E-06	1.365E-02	CNR1, CNR2
CC	GO:0044464; cell part	GO:0043204; perikaryon	8.178E-07	1.365E-02	CNR2, MAPK1, SMN1, SMN2
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	2.507E-06	1.820E-02	CNR1, CNR2
BP	GO:0032501; multicellular organismal process	GO:0019233; sensory perception of pain	5.471E-06	2.781E-02	CNR1, CNR2, MAPK1
CC	GO:0044464; cell part	GO:0043005; neuron projection	6.386E-06	2.781E-02	CNR1, CNR2, MAPK1, MAPT, SMN1, SMN2
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	8.764E-06	3.181E-02	CNR1, CNR2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.568E-04	1.709E-02	ALOX15, CYP3A4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6.782E-04	2.880E-02	CNR2, CNR1, TSHR
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.927E-04	2.880E-02	ALDH1A1, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.899E-03	4.230E-02	CNR1, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	2.247E-03	4.230E-02	MMP3, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.329E-03	4.230E-02	ALOX15, MAPK1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.608E-03	5.618E-02	LMNA, MAPK1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	5.148E-03	6.527E-02	MAPK1, MAPT
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	5.389E-03	6.527E-02	SMN2, SMN1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	7.149E-03	7.084E-02	MAPK1, TSHR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Ischemic stroke	I61-I63	MMP3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP3;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP3;
A00-B99: Certain infectious and parasitic diseases	HCV infection	B17.1, B18.2	MMP3;
H00-H59: Diseases of the eye and adnexa	Corneal ulcers	H16.0	MMP3;
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	MMP3;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases