CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 0 group B	NR0B1;
Nuclear hormone receptor subfamily 3 group C	NR3C1;
Transcription Factor	HIF1A;
SLC superfamily of solute carriers	SLC6A2; SLC6A3; SLCO1B3; SLCO1B1;
Unclassified	PAX8; RAB9A; NPC1; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 0 group B	NR0B1	Nuclear receptor subfamily 0 group B member 1	P51843	CHEMBL1795094
Nuclear hormone receptor subfamily 3 group C	NR3C1	Glucocorticoid receptor	P04150	CHEMBL2034
SLC superfamily of solute carriers	SLC6A2	Norepinephrine transporter	P23975	CHEMBL222
SLC superfamily of solute carriers	SLC6A3	Dopamine transporter	Q01959	CHEMBL238
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.312E-09	2.028E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.021E-07	5.559E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.278E-06	5.567E-03	CYP2C19, CYP2C9, CYP3A4, NPC1, NR0B1
BP	GO:0023052; signaling	GO:0051583; dopamine uptake involved in synaptic transmission	9.631E-06	1.311E-02	SLC6A2, SLC6A3
BP	GO:0009987; cellular process	GO:2001054; negative regulation of mesenchymal cell apoptotic process	2.884E-05	2.990E-02	HIF1A, PAX8
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	4.225E-05	3.539E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	4.991E-05	3.748E-02	SMN1, SMN2
MF	GO:0005215; transporter activity	GO:0005330; dopamine:sodium symporter activity	1.929E-06	6.168E-03	SLC6A2, SLC6A3
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.747E-06	7.477E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.856E-06	8.396E-03	CYP2C9, CYP3A4

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.516E-06	5.304E-05	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.131E-05	2.710E-04	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.103E-03	7.070E-03	CYP2C9, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.212E-03	7.070E-03	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.526E-03	7.628E-03	CYP2C9, CYP3A4
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	8.152E-03	3.170E-02	SMN2, SMN1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.323E-05	2.710E-04	SLCO1B1, SLCO1B3, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.543E-03	1.550E-02	CYP2C9, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.579E-05	3.132E-04	CYP2C9, CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.296E-02	8.035E-02	PAX8

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	NR3C1;
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; NR3C1;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Cushing's disease	E24.0	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Xerophthalmia	E50.6-E50.7	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	NR3C1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Crotalaria lechnaultii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities