Plant Name: Strychnos usambarensis
Taxonomic Information:
Plant ID: NPO18713
Plant Latin Name: Strychnos usambarensis
Taxonomy Genus: Strychnos
Taxonomy Family: Loganiaceae
Plant External Links:
NCBI TaxonomyDB:
992791
Plant-of-the-World-Online:
547543-1
Used in Medicines:
Unknown.
Geographical Distribution:
Ghana; Liberia; Madagascar; Rwanda; Uganda; South Africa; Guinea; Tanzania; Zimbabwe; Burkina Faso; Congo; Mozambique; Sierra Leone; Swaziland; Burundi; Kenya; Nigeria; Cote d'Ivoire; Zambia; Benin
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| RECQL; | |
| SMN1;SMN2; | |
| MAPT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0048699; generation of neurons | 1.242E-03 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:1990000; amyloid fibril formation | 1.242E-03 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:0019896; axonal transport of mitochondrion | 1.397E-03 | 1.000E+00 | MAPT |
| BP | GO:0032501; multicellular organismal process | GO:0048143; astrocyte activation | 1.397E-03 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 1.397E-03 | 1.000E+00 | RECQL |
| BP | GO:0008152; metabolic process | GO:0032930; positive regulation of superoxide anion generation | 2.173E-03 | 1.000E+00 | MAPT |
| BP | GO:0002376; immune system process | GO:0001774; microglial cell activation | 2.638E-03 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:1901216; positive regulation of neuron death | 1.191E-02 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:1900034; regulation of cellular response to heat | 1.207E-02 | 1.000E+00 | MAPT |
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 1.268E-02 | 1.000E+00 | MAPT |
| BP | GO:0007610; behavior | GO:0007613; memory | 1.622E-02 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:0050808; synapse organization | 2.205E-02 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:2001020; regulation of response to DNA damage stimulus | 2.755E-02 | 1.000E+00 | MAPT |
| BP | GO:0008152; metabolic process | GO:0010506; regulation of autophagy | 4.693E-02 | 1.000E+00 | MAPT |
| CC | GO:0044464; cell part | GO:0030673; axolemma | 2.483E-03 | 1.000E+00 | MAPT |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 1.037E-02 | 1.000E+00 | MAPT |
| CC | GO:0044464; cell part | GO:0036464; cytoplasmic ribonucleoprotein granule | 2.846E-02 | 1.000E+00 | MAPT |
| MF | GO:0003824; catalytic activity | GO:0009378; four-way junction helicase activity | 7.764E-04 | 1.000E+00 | RECQL |
| MF | GO:0003824; catalytic activity | GO:0043140; ATP-dependent 3'-5' DNA helicase activity | 1.087E-03 | 1.000E+00 | RECQL |
| MF | GO:0005488; binding | GO:0036310; annealing helicase activity | 1.242E-03 | 1.000E+00 | RECQL |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 1.708E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0034185; apolipoprotein binding | 2.483E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 4.343E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 4.962E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0003677; DNA binding | 4.580E-02 | 1.000E+00 | MAPT, RECQL |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.499E-02 | 3.777E-02 | MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 3.777E-02 | 3.777E-02 | MAPT |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
