CMAUP Plant Collective Molecular Activities

Plant Name: Saussurea involucrata

Taxonomic Information:

Plant ID: NPO18671
Plant Latin Name: Saussurea involucrata
Taxonomy Genus: Saussurea
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 200489
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Hydrolase	ACHE;
Protein Kinase	PIM1; MET; AXL; FLT3; CDK1; KDR; IGF1R; AURKB; CSNK2A1;
Lyase	CA12; CA9; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Enzyme_unclassified	AKR1B10; ALOX12; HSD17B1; AKR1B1; GFER; HSD17B10; NOX4; POLB;
Metallo protease	MMP9; MMP1; MMP12; MMP2;
Transcription Factor	HIF1A; NFKB1;
Unclassified	THPO; APP;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.531E-08	1.784E-05	CA12, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.250E-08	2.130E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	9.827E-08	6.733E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	6.060E-07	2.693E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.422E-07	2.797E-04	CA12, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	7.692E-07	3.102E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.464E-06	4.981E-04	CA12, CA4, CA7, CA9
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	1.715E-06	5.413E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.809E-06	5.627E-04	AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1
MF	GO:0005488; binding	GO:0020037; heme binding	4.344E-06	1.113E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	5.498E-06	1.345E-03	AKR1B1, AXL, CDK1, CYP1B1
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	7.094E-06	1.679E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	8.403E-06	1.946E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.116E-05	2.454E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.289E-05	2.725E-03	ALOX12, CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	1.324E-05	2.746E-03	AXL, CDK1, CSNK2A1, FLT3
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	1.545E-05	3.057E-03	MMP1, MMP12, MMP2, MMP9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.705E-05	3.345E-03	CA12, CA4, CA7, CA9, ESR2, MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.137E-05	4.082E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	2.663E-05	4.914E-03	AXL, FLT3, IGF1R, KDR, MET
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	3.088E-05	5.512E-03	CSNK2A1, HIF1A, KDR
BP	GO:0050896; response to stimulus	GO:1901653; cellular response to peptide	4.544E-05	7.536E-03	AKR1B1, APP, IGF1R, NFKB1, TSHR
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	4.984E-05	8.038E-03	APP, CYP1A1, CYP1B1, FLT3, NFKB1, NOX4
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	5.295E-05	8.295E-03	AKR1B1, CYP19A1, CYP1A2, NOX4

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.263E-08	1.925E-06	HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.240E-07	1.546E-05	FLT3, MMP1, MMP2, HIF1A, MET, MMP9, NFKB1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6.982E-08	2.746E-06	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.318E-08	1.925E-06	CA12, CA4, CA7, CA9
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.816E-06	4.286E-05	MMP2, KDR, HIF1A, MMP9, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.928E-05	3.791E-04	FLT3, MMP9, MET, NFKB1, IGF1R
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.493E-05	8.731E-04	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	5.919E-05	8.731E-04	MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.592E-04	2.087E-03	FLT3, PIM1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	2.062E-04	2.433E-03	PIM1, CYP1B1, MMP9, MET, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.573E-04	2.761E-03	FLT3, MET, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	7.956E-04	5.949E-03	KDR, MET, NFKB1, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.316E-04	3.133E-03	CYP1A2, CYP1A1, CYP1B1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.451E-04	3.133E-03	CSNK2A1, MET, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8.574E-04	5.949E-03	MMP2, PIM1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	8.090E-04	5.949E-03	MMP2, MMP9, ESR2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.668E-04	3.934E-03	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	9.075E-04	5.949E-03	HIF1A, NFKB1, IGF1R
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.631E-03	8.748E-03	AKR1B10, HSD17B1, CYP1A2, CYP1A1, AKR1B1, ALOX12, CYP19A1, HSD17B10
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1.411E-03	8.325E-03	THPO, FLT3, KDR, MET
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.402E-03	8.325E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.595E-03	8.748E-03	AKR1B10, AKR1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; APP;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; AKR1B1;
NA: NA	Geographic retinal atrophy	NA	APP;
C00-D49: Neoplasms	Glioma	C71	KDR; APP;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; AKR1B1;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; HIF1A; MMP9; MMP2; CA9;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1; APP;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; MMP1;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CYP19A1; CA9;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; CSNK2A1; NFKB1; FLT3; ACHE; HIF1A; MMP9; MMP2; APP; CA9;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	CLL	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE; APP;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; MMP2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases