CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	AURKB; AURKA; KDR;
Lyase	CA7; CA4; CA12;
Lysine demethylase	KDM4E;
ATP-binding cassette	ABCG2;
Unclassified	HTT; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.293E-06	1.408E-02	CA12, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.392E-06	1.736E-02	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.588E-05	3.898E-02	CYP1A1, CYP1B1
BP	GO:0008152; metabolic process	GO:0035404; histone-serine phosphorylation	2.327E-05	3.898E-02	AURKA, AURKB
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	3.534E-06	1.923E-02	AURKA, AURKB
CC	GO:0043226; organelle	GO:0000780; condensed nuclear chromosome, centromeric region	2.327E-05	3.898E-02	AURKA, AURKB
CC	GO:0043226; organelle	GO:0031616; spindle pole centrosome	2.327E-05	3.898E-02	AURKA, AURKB
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.300E-08	1.807E-03	CA12, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0035174; histone serine kinase activity	5.300E-06	1.923E-02	AURKA, AURKB
MF	GO:0003824; catalytic activity	GO:0003824; catalytic activity	1.954E-05	3.898E-02	ABCG2, AURKA, AURKB, CA12, CA4, CA7, CYP1A1, CYP1B1, KDM4E, KDR, RAB9A

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.117E-07	2.569E-06	CA12, CA4, CA7
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.542E-04	2.923E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.354E-04	3.079E-03	CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.470E-04	3.896E-03	CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.832E-02	8.738E-02	CYP1A1
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	3.600E-02	8.738E-02	KDR
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	2.609E-02	7.501E-02	ABCG2
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.979E-04	3.050E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.372E-02	4.507E-02	CA4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.067E-03	4.091E-03	CYP1A1, CYP1B1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Cancer	C00-C96	AURKA; KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Breast cancer	C50	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Clerodendranthus spicatus

Taxonomic Information:

Plant External Links:

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities