CMAUP Plant Collective Molecular Activities

Plant Name: Fagopyrum cymosum

Taxonomic Information:

Plant ID: NPO18608
Plant Latin Name: Fagopyrum cymosum
Taxonomy Genus: Fagopyrum
Taxonomy Family: Polygonaceae

Plant External Links:

NCBI TaxonomyDB: 62329
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand

Traditional Medicine System:

Geographical Distribution:

Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA1; CA5B; CA5A; CA6; CA12;
SLC superfamily of solute carriers	SLCO1B3;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.525E-13	3.838E-09	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.015E-12	7.366E-09	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.554E-06	5.055E-03	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.813E-15	6.126E-11	CA1, CA12, CA5A, CA5B, CA6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.871E-15	2.922E-14	CA12, CA1, CA5B, CA5A, CA6
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.459E-02	3.730E-02	SLCO1B3
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	2.562E-02	3.730E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	2.870E-02	3.730E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	3.108E-02	3.730E-02	LMNA
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.799E-02	4.799E-02	LMNA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases