Plant Name: Lantana camara
Taxonomic Information:
Plant ID: NPO1859
Plant Latin Name: Lantana camara
Taxonomy Genus: Lantana
Taxonomy Family: Verbenaceae
Plant External Links:
NCBI TaxonomyDB:
126435
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Brazil; Australia; Indonesia; South Africa; Guinea; Philippines; Mexico; India; Congo; United States; Malaysia; Rwanda; China; Vietnam; Thailand; Kenya; Nigeria; Venezuela; TanzaniaTraditional Medicine System:
Indian Folk; TCM; AyurvedaGeographical Distribution:
Brazil; Australia; Rwanda; Mexico; Guinea; Philippines; Indonesia; India; South Africa; United States; Malaysia; Congo; China; Vietnam; Thailand; Kenya; Nigeria; Venezuela; Tanzania
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| EGFR; | |
| PPARD; PPARA; | |
| ALOX5; | |
| F2; CTRC; PRSS1; | |
| TLR2; | |
| FABP3; FABP2; FABP4; FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | EGFR | Epidermal growth factor receptor erbB1 | P00533 | CHEMBL203 |
| Serine protease | F2 | Thrombin | P00734 | CHEMBL204 |
| Serine protease | CTRC | Chymotrypsin C | Q99895 | CHEMBL2386 |
| Serine protease | PRSS1 | Trypsin I | P07477 | CHEMBL209 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 1.548E-09 | 1.123E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 1.113E-05 | 1.101E-02 | FABP3, PPARA, PPARD |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 1.693E-05 | 1.602E-02 | EGFR, PPARA, PPARD |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 2.292E-05 | 1.996E-02 | PPARA, PPARD |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 2.292E-05 | 1.996E-02 | FABP3, PPARD |
| BP | GO:0009987; cellular process | GO:0014066; regulation of phosphatidylinositol 3-kinase signaling | 3.385E-05 | 2.534E-02 | EGFR, F2, PPARD |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 2.273E-12 | 1.545E-10 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 5.889E-04 | 1.537E-02 | FABP4, TSHR |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 6.782E-04 | 1.537E-02 | PRSS1, F2, TSHR |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 2.580E-03 | 4.386E-02 | ALOX5, TLR2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 3.263E-03 | 4.438E-02 | PPARA, EGFR |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 7.429E-03 | 6.991E-02 | EGFR, TLR2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 7.149E-03 | 6.991E-02 | PPARA, TSHR |
| 09140 Cellular Processes | 09142 Cell motility | hsa04810 | Regulation of actin cytoskeleton | 8.225E-03 | 6.991E-02 | F2, EGFR |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 4.519E-02 | 9.870E-02 | EGFR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 4.457E-02 | 9.870E-02 | PPARA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Thrombocytopenia | D69.6, P61.0 | F2; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | F2; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | F2; |
| O00-O9A: Pregnancy, childbirth and the puerperium | Premature labour | O60.1, P07.3 | PRSS1; |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | F2; |
| I00-I99: Diseases of the circulatory system | Venous thromboembolism | I80-I82 | F2; |
| I00-I99: Diseases of the circulatory system | Venous thrombosis | I80-I82 | F2; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Blood forming organ disorders | D75.9 | F2; |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | F2; |
| I00-I99: Diseases of the circulatory system | Angina pectoris | I20 | F2; |
| C00-D49: Neoplasms | Cancer | C00-C96 | F2; |
| I00-I99: Diseases of the circulatory system | Bleeding | I74, I80-I82 | F2; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Blood coagulation disorders | D65-D68 | PRSS1; F2; |
| I00-I99: Diseases of the circulatory system | Stroke in atrial fibrillation | I48, I61-I63 | F2; |
| I00-I99: Diseases of the circulatory system | Heart arrhythmia | I47-I49 | F2; |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | F2; |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | F2; |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PRSS1; |
| I00-I99: Diseases of the circulatory system | Coagulation | I80-I82 | F2; |
| G00-G99: Diseases of the nervous system G00-G99 | Multiple scierosis | G35 | F2; |
| I00-I99: Diseases of the circulatory system | Hypotension | I95 | PRSS1; |
| NA: NA | Nonvalvular atrial fibrillation | NA | F2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | F2; |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | F2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
