Plant Name: Pyrrosia davidii
Taxonomic Information:
Plant ID: NPO18581
Plant Latin Name: Pyrrosia davidii
Taxonomy Genus: Pyrrosia
Taxonomy Family: Polypodiaceae
Plant External Links:
NCBI TaxonomyDB:
872851
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TRPA1; | |
| AKR1B1; AKR1B10; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0044597; daunorubicin metabolic process | 9.002E-07 | 6.300E-03 | AKR1B1, AKR1B10 |
| BP | GO:0008152; metabolic process | GO:0044598; doxorubicin metabolic process | 9.002E-07 | 6.300E-03 | AKR1B1, AKR1B10 |
| MF | GO:0003824; catalytic activity | GO:0004033; aldo-keto reductase (NADP) activity | 1.044E-05 | 3.787E-02 | AKR1B1, AKR1B10 |
| CC | GO:0044464; cell part | GO:0032421; stereocilium bundle | 1.035E-03 | 4.900E-01 | TRPA1 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 1.180E-03 | 5.322E-01 | AKR1B1, AKR1B10 |
| CC | GO:0044464; cell part | GO:0099568; cytoplasmic region | 4.158E-02 | 1.000E+00 | AKR1B1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 1.886E-05 | 6.286E-05 | AKR1B10, AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.303E-05 | 6.286E-05 | AKR1B10, AKR1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 5.114E-05 | 1.278E-04 | AKR1B10, AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.485E-05 | 6.286E-05 | AKR1B10, AKR1B1 |
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.946E-02 | 2.351E-02 | TRPA1 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 2.351E-02 | LMNA |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 2.116E-02 | 2.351E-02 | AKR1B10, AKR1B1 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.650E-02 | 2.351E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.788E-02 | 2.351E-02 | LMNA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.771E-02 | 2.771E-02 | LMNA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
