CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR7; HTR2A; HTR1A;
Protein Kinase	CDK2; CDK4; AURKB; AURKA; CDK1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Protein Kinase	CDK2	Cyclin-dependent kinase 2	P24941	CHEMBL301
Protein Kinase	CDK4	Cyclin-dependent kinase 4	P11802	CHEMBL331
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Small molecule receptor (family A GPCR)	HTR7	Serotonin 7 (5-HT7) receptor	P34969	CHEMBL3155
Small molecule receptor (family A GPCR)	HTR2A	Serotonin 2a (5-HT2a) receptor	P28223	CHEMBL224
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214

Showing 1 to 9 of 9 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	1.409E-07	2.556E-04	HTR1A, HTR2A, HTR7
BP	Unclassified;	GO:0042310; vasoconstriction	2.540E-07	3.951E-04	HTR1A, HTR2A, HTR7
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	1.157E-06	9.334E-04	HTR1A, HTR7
BP	GO:0009987; cellular process	GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	2.609E-06	1.387E-03	AURKA, CDK1, CDK2
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	4.834E-06	2.105E-03	AURKA, CDK1, CDK4
BP	GO:0008152; metabolic process	GO:0031145; anaphase-promoting complex-dependent catabolic process	5.644E-06	2.276E-03	AURKA, AURKB, CDK1
BP	GO:0009987; cellular process	GO:0010972; negative regulation of G2/M transition of mitotic cell cycle	9.179E-06	3.276E-03	AURKA, AURKB, CDK1
BP	GO:0008152; metabolic process	GO:0035404; histone-serine phosphorylation	1.271E-05	4.177E-03	AURKA, AURKB
BP	GO:0051179; localization	GO:0034501; protein localization to kinetochore	1.501E-05	4.540E-03	AURKB, CDK1
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	2.109E-05	5.812E-03	HTR1A, HTR2A, HTR7

Showing 1 to 10 of 24 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.075E-04	1.176E-03	HTR7, HTR1A, HTR2A
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	2.782E-03	7.678E-03	HTR7, HTR2A
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	3.253E-06	5.529E-05	CDK4, CDK2, CDK1
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	1.856E-05	1.616E-04	CDK2, CDK1, AURKA
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	1.902E-05	1.616E-04	CDK4, CDK2, CDK1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	6.754E-04	2.870E-03	CDK1, HTR2A
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.149E-07	3.907E-06	HTR7, CYP2D6, HTR1A, HTR2A
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8.366E-04	3.161E-03	CDK2, CDK1
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	8.518E-05	5.792E-04	CDK4, CDK2, CDK1
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	6.452E-04	2.870E-03	CDK4, CDK2

Showing 1 to 10 of 14 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CDK2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	CDK2;
C00-D49: Neoplasms	Solid tumours	C00-D48	CDK2;
C00-D49: Neoplasms	Breast cancer	C50	CDK1;
C00-D49: Neoplasms	Cancer	C00-C96	CDK2; CDK1;
C00-D49: Neoplasms	Thymoma	C37, D15.0	CDK2;
E00-E89: Endocrine, nutritional and metabolic diseases	Erythropoietic porphyria	E80.0	HTR2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HTR2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A;

Showing 1 to 10 of 48 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Fissistigma oldhamii

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities