CMAUP Plant Collective Molecular Activities

Plant Name: Arundo donax

Taxonomic Information:

Plant ID: NPO18498
Plant Latin Name: Arundo donax
Taxonomy Genus: Arundo
Taxonomy Family: Poaceae

Plant External Links:

NCBI TaxonomyDB: 35708
Plant-of-the-World-Online: 390837-1

Used in Medicines:

Country/Region:

Lebanon; Italy; China; India; Thailand

Traditional Medicine System:

TCM; Homeopathy; Ayurveda; Siddha

Medicinal Functions:

Diaphoretic; Diuretic; Emollient; Galactofuge; Hypotensive

Geographical Distribution:

Brazil; Afghanistan; Madagascar; Italy; Bangladesh; Lebanon; Nepal; Costa Rica; Cambodia; France; Bahamas; Ethiopia; Trinidad and Tobago; Somalia; Peru; Laos; Argentina; Bolivia; Vanuatu; Ecuador; Turkmenistan; Saudi Arabia; Australia; Iran; Algeria; Cuba; El Salvador; Turkey; Venezuela; Cape Verde; Russia; Suriname; Guatemala; China; Chile; Tajikistan; Thailand; Dominican Republic; Iraq; Kazakhstan; Spain; Georgia; Libya; Pakistan; Oman; Philippines; Indonesia; New Caledonia; United States; Morocco; Seychelles; French Guiana; Namibia; New Zealand; Yemen; Haiti; Jamaica; Albania; Portugal; Myanmar; Mexico; Egypt; Fiji; South Africa; India; Nicaragua; Uzbekistan; Tunisia; Austria; Vietnam; Colombia; Greece; Sri Lanka; Japan; Cyprus; Botswana

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR2B; HTR2A; HTR1A; HTR2C;
Protein Phosphatase	PTPN1;
SLC superfamily of solute carriers	SLC6A4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
SLC superfamily of solute carriers	SLC6A4	Serotonin transporter	P31645	CHEMBL228
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Small molecule receptor (family A GPCR)	HTR2A	Serotonin 2a (5-HT2a) receptor	P28223	CHEMBL224
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0051378; serotonin binding	3.979E-12	4.332E-08	HTR1A, HTR2A, HTR2B, HTR2C
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	1.279E-10	3.977E-07	HTR1A, HTR2A, HTR2B, HTR2C
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	1.279E-10	3.977E-07	HTR1A, HTR2A, HTR2B, HTR2C
BP	Unclassified;	GO:0042310; vasoconstriction	2.855E-10	7.772E-07	HTR1A, HTR2A, HTR2B, SLC6A4
BP	GO:0008152; metabolic process	GO:0010513; positive regulation of phosphatidylinositol biosynthetic process	4.661E-10	1.128E-06	HTR2A, HTR2B, HTR2C
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	1.110E-07	1.272E-04	HTR1A, HTR2A, HTR2B, SLC6A4
BP	GO:0009987; cellular process	GO:0007208; phospholipase C-activating serotonin receptor signaling pathway	1.501E-07	1.421E-04	HTR2A, HTR2C
MF	GO:0005488; binding	GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	1.501E-07	1.421E-04	HTR2A, HTR2C
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.502E-07	3.921E-04	CYP2D6, CYP3A4
BP	GO:0051179; localization	GO:0051209; release of sequestered calcium ion into cytosol	6.563E-07	5.104E-04	HTR2A, HTR2B, HTR2C
BP	GO:0007610; behavior	GO:0050795; regulation of behavior	1.920E-06	1.230E-03	HTR1A, HTR2A, HTR2B
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.250E-06	1.400E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0070372; regulation of ERK1 and ERK2 cascade	2.651E-06	1.600E-03	HTR2A, HTR2B, HTR2C, PTPN1
BP	GO:0009987; cellular process	GO:0014062; regulation of serotonin secretion	3.149E-06	1.714E-03	HTR1A, SLC6A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	9.886E-06	4.580E-03	CYP2D6, CYP3A4
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	9.528E-05	2.730E-02	HTR1A, HTR2A, HTR2B, HTR2C, SLC6A4
CC	GO:0044464; cell part	GO:0097443; sorting endosome	2.483E-03	2.361E-01	PTPN1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	7.473E-13	1.420E-11	CYP2D6, HTR1A, HTR2B, HTR2C, HTR2A, SLC6A4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.413E-06	2.292E-05	HTR1A, HTR2B, HTR2C, HTR2A
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6.276E-06	2.981E-05	HTR2B, HTR2C, HTR2A
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	4.537E-06	2.873E-05	HTR2B, HTR2C, HTR2A
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	3.884E-05	1.476E-04	HTR2B, HTR2C, HTR2A
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.241E-04	9.846E-04	CYP2D6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.627E-04	9.846E-04	CYP2D6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.826E-02	3.854E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.154E-02	2.742E-02	CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.571E-02	4.145E-02	CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	Addiction	NA	HTR2A;
NA: NA	Episode	NA	HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Erythropoietic porphyria	E80.0	HTR2A;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR2C;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	HTR2B;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR2C;
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HTR1A;
I00-I99: Diseases of the circulatory system	Hemorrhoids	I84	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	HTR2C;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR1A;
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	HTR2B;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	HTR2A;
NA: NA	Cervical dystonia	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2A; HTR2B; HTR2C; HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HTR2A; HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR2A;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	HTR2C; HTR1A;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR2A; HTR2C; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A;
NA: NA	Bulimia nervosa	NA	HTR1A;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	HTR2A;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HTR2A;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	HTR2C; HTR1A;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR2A; HTR1A;
C00-D49: Neoplasms	Aggressive non-hodgkin's lymphoma	C81, C81-C86, C82-C85, C91-C95	HTR2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B;
NA: NA	Social phobia	NA	HTR1A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A;
NA: NA	Primary insomnia	NA	HTR2C;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep maintenance insomnia	F51.0, G47.0	HTR2A;
NA: NA	Sleep initiation and maintenance disorders	NA	HTR2C;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	HTR2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR2C; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR2A; HTR2C; HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	HTR1A;
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	HTR2A;
NA: NA	Schizoaffective disorder	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	HTR2A; HTR2C;
NA: NA	Peripheral sensory neuropathies	NA	HTR1A;
NA: NA	Anxiety disorders	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR2A; HTR2C; HTR1A;
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A;
I00-I99: Diseases of the circulatory system	Coronary heart disease	I25.1	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR2C; HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR2A; HTR2B; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases