CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0061370; testosterone biosynthetic process	5.177E-04	1.000E+00	CYP19A1
BP	GO:0032501; multicellular organismal process	GO:0060736; prostate gland growth	1.139E-03	1.000E+00	CYP19A1
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	1.346E-03	1.000E+00	CYP19A1
BP	GO:0032502; developmental process	GO:0060065; uterus development	1.449E-03	1.000E+00	CYP19A1
BP	GO:0032501; multicellular organismal process	GO:0030540; female genitalia development	1.656E-03	1.000E+00	CYP19A1
BP	GO:0032501; multicellular organismal process	GO:0008585; female gonad development	1.966E-03	1.000E+00	CYP19A1
BP	GO:0032502; developmental process	GO:0030879; mammary gland development	2.277E-03	1.000E+00	CYP19A1
BP	GO:0008152; metabolic process	GO:0016125; sterol metabolic process	1.321E-02	1.000E+00	CYP19A1
BP	GO:0008152; metabolic process	GO:0022900; electron transport chain	1.670E-02	1.000E+00	CYP19A1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.380E-03	1.000E+00	CYP19A1

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.792E-03	8.688E-03	CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	4.994E-03	8.688E-03	CYP19A1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.201E-01	1.201E-01	CYP19A1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Lophopetalum toxicum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities