Plant Name: Cryptocarya triplinervis
Taxonomic Information:
Plant ID: NPO18465
Plant Latin Name: Cryptocarya triplinervis
Taxonomy Genus: Cryptocarya
Taxonomy Family: Lauraceae
Plant External Links:
NCBI TaxonomyDB:
136115
Plant-of-the-World-Online:
464161-1
Used in Medicines:
Unknown.
Geographical Distribution:
Australia; Indonesia
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TRPA1; | |
| ALOX15; | |
| PTGS1; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 4.586E-05 | 3.329E-01 | ALOX15, PTGS1 |
| MF | GO:0003824; catalytic activity | GO:0051213; dioxygenase activity | 1.280E-04 | 4.099E-01 | ALOX15, PTGS1 |
| MF | GO:0003824; catalytic activity | GO:0004666; prostaglandin-endoperoxide synthase activity | 4.141E-04 | 4.294E-01 | PTGS1 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 4.141E-04 | 4.294E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0050473; arachidonate 15-lipoxygenase activity | 6.212E-04 | 4.664E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 6.212E-04 | 4.664E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 6.212E-04 | 4.664E-01 | ALOX15 |
| CC | GO:0044464; cell part | GO:0032421; stereocilium bundle | 1.035E-03 | 6.440E-01 | TRPA1 |
| CC | GO:0016020; membrane | GO:0016020; membrane | 2.625E-02 | 1.000E+00 | ALOX15, LMNA, PTGS1, TRPA1 |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 3.333E-02 | 1.000E+00 | LMNA |
| CC | GO:0044425; membrane part | GO:0019898; extrinsic component of membrane | 3.998E-02 | 1.000E+00 | ALOX15 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 5.651E-05 | 6.216E-04 | ALOX15, PTGS1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.851E-04 | 1.018E-03 | ALOX15, PTGS1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.788E-03 | 2.122E-02 | ALOX15 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.115E-02 | 2.586E-02 | PTGS1 |
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.946E-02 | 2.586E-02 | TRPA1 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 2.586E-02 | LMNA |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 2.116E-02 | 2.586E-02 | ALOX15, PTGS1 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.650E-02 | 2.586E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.788E-02 | 2.586E-02 | LMNA |
| 09150 Organismal Systems | 09151 Immune system | hsa04611 | Platelet activation | 2.418E-02 | 2.660E-02 | PTGS1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
