Plant Name: Trema dielsiana
Taxonomic Information:
Plant ID: NPO18460
Plant Latin Name: Trema dielsiana
Taxonomy Genus: Trema
Taxonomy Family: Cannabaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Plant homeodomain | KMT2A | Histone-lysine N-methyltransferase MLL | Q03164 | CHEMBL1293299 |
| Protein Kinase | DYRK2 | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | Q92630 | CHEMBL4376 |
| Protein Kinase | HASPIN | Serine/threonine-protein kinase haspin | Q8TF76 | CHEMBL1075163 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | Unclassified; | GO:0051534; negative regulation of NFAT protein import into nucleus | 1.035E-03 | 1.000E+00 | DYRK2 |
| BP | GO:0032501; multicellular organismal process | GO:0055015; ventricular cardiac muscle cell development | 2.069E-03 | 1.000E+00 | LMNA |
| BP | GO:0008152; metabolic process | GO:2000615; regulation of histone H3-K9 acetylation | 2.896E-03 | 1.000E+00 | KMT2A |
| BP | Unclassified; | GO:0051571; positive regulation of histone H3-K4 methylation | 3.103E-03 | 1.000E+00 | KMT2A |
| BP | GO:0009987; cellular process | GO:0090201; negative regulation of release of cytochrome c from mitochondria | 3.516E-03 | 1.000E+00 | LMNA |
| BP | GO:0051179; localization | GO:0071459; protein localization to chromosome, centromeric region | 3.723E-03 | 1.000E+00 | HASPIN |
| BP | GO:0032501; multicellular organismal process | GO:0035162; embryonic hemopoiesis | 3.929E-03 | 1.000E+00 | KMT2A |
| BP | GO:0009987; cellular process | GO:0007077; mitotic nuclear envelope disassembly | 9.081E-03 | 1.000E+00 | LMNA |
| BP | GO:0007610; behavior | GO:0008542; visual learning | 9.904E-03 | 1.000E+00 | KMT2A |
| BP | GO:0032501; multicellular organismal process | GO:0032922; circadian regulation of gene expression | 1.134E-02 | 1.000E+00 | KMT2A |
| BP | GO:0065007; biological regulation | GO:0051899; membrane depolarization | 1.298E-02 | 1.000E+00 | KMT2A |
| BP | GO:0032501; multicellular organismal process | GO:0009791; post-embryonic development | 1.503E-02 | 1.000E+00 | KMT2A |
| BP | GO:0050896; response to stimulus | GO:0009628; response to abiotic stimulus | 1.515E-02 | 1.000E+00 | KMT2A, LMNA |
| BP | GO:0023052; signaling | GO:0023051; regulation of signaling | 1.929E-02 | 1.000E+00 | DYRK2, KMT2A, LMNA |
| BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 2.116E-02 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 2.136E-02 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:1901796; regulation of signal transduction by p53 class mediator | 3.595E-02 | 1.000E+00 | DYRK2 |
| BP | GO:0008152; metabolic process | GO:0018108; peptidyl-tyrosine phosphorylation | 3.797E-02 | 1.000E+00 | DYRK2 |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 3.333E-02 | 1.000E+00 | LMNA |
| MF | GO:0003824; catalytic activity | GO:0004712; protein serine/threonine/tyrosine kinase activity | 8.670E-03 | 1.000E+00 | DYRK2 |
| MF | GO:0005488; binding | GO:0001046; core promoter sequence-specific DNA binding | 2.299E-02 | 1.000E+00 | KMT2A |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 3.159E-02 | 1.000E+00 | DYRK2, HASPIN |
| MF | GO:0003824; catalytic activity | GO:0004713; protein tyrosine kinase activity | 3.696E-02 | 1.000E+00 | DYRK2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00310 | Lysine degradation | 1.036E-02 | 2.682E-02 | KMT2A |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 2.682E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.650E-02 | 2.682E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.788E-02 | 2.682E-02 | LMNA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.771E-02 | 3.325E-02 | LMNA |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 3.552E-02 | 3.552E-02 | KMT2A |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
