CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	DYRK2; HASPIN;
Plant homeodomain	KMT2A;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Protein Kinase	DYRK2	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Q92630	CHEMBL4376
Protein Kinase	HASPIN	Serine/threonine-protein kinase haspin	Q8TF76	CHEMBL1075163
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 4 of 4 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	Unclassified;	GO:0051534; negative regulation of NFAT protein import into nucleus	1.035E-03	1.000E+00	DYRK2
BP	GO:0032501; multicellular organismal process	GO:0055015; ventricular cardiac muscle cell development	2.069E-03	1.000E+00	LMNA
BP	GO:0008152; metabolic process	GO:2000615; regulation of histone H3-K9 acetylation	2.896E-03	1.000E+00	KMT2A
BP	Unclassified;	GO:0051571; positive regulation of histone H3-K4 methylation	3.103E-03	1.000E+00	KMT2A
BP	GO:0009987; cellular process	GO:0090201; negative regulation of release of cytochrome c from mitochondria	3.516E-03	1.000E+00	LMNA
BP	GO:0051179; localization	GO:0071459; protein localization to chromosome, centromeric region	3.723E-03	1.000E+00	HASPIN
BP	GO:0032501; multicellular organismal process	GO:0035162; embryonic hemopoiesis	3.929E-03	1.000E+00	KMT2A
BP	GO:0009987; cellular process	GO:0007077; mitotic nuclear envelope disassembly	9.081E-03	1.000E+00	LMNA
BP	GO:0007610; behavior	GO:0008542; visual learning	9.904E-03	1.000E+00	KMT2A
BP	GO:0032501; multicellular organismal process	GO:0032922; circadian regulation of gene expression	1.134E-02	1.000E+00	KMT2A

Showing 1 to 10 of 23 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00310	Lysine degradation	1.036E-02	2.682E-02	KMT2A
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.771E-02	3.325E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.472E-02	2.682E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	1.650E-02	2.682E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.788E-02	2.682E-02	LMNA
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	3.552E-02	3.552E-02	KMT2A

Showing 1 to 6 of 6 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Trema dielsiana

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities