CMAUP Plant Collective Molecular Activities

Plant Name: Aristolochia manshuriensis

Taxonomic Information:

Plant ID: NPO18443
Plant Latin Name: Aristolochia manshuriensis
Taxonomy Genus: Aristolochia
Taxonomy Family: Aristolochiaceae

Plant External Links:

NCBI TaxonomyDB: 158555
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Enzyme_unclassified	PLA2G1B; AKR1B10; POLB;
Protein Kinase	CDK2; CDK1; CDK4; AURKB; AURKA;
Lyase	CA1; CA12; CA9; CA2; CA5B; CA3; CA14; CA7; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Protein Kinase	CDK2	Cyclin-dependent kinase 2	P24941	CHEMBL301
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	CDK4	Cyclin-dependent kinase 4	P11802	CHEMBL331
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.296E-11	1.589E-07	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2, NR1H4, PTPN1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.130E-29	4.637E-25	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	9.540E-07	1.039E-03	CDK4, NR1H4, PTPN1, PTPN2
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	1.313E-06	1.299E-03	AURKA, AURKB, CDK1, POLB
BP	GO:0009987; cellular process	GO:0090068; positive regulation of cell cycle process	3.440E-06	3.121E-03	AURKA, AURKB, CDC25B, CDK1, CDK2, CDK4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.989E-06	5.073E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	6.989E-06	5.073E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	6.989E-06	5.073E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902751; positive regulation of cell cycle G2/M phase transition	7.598E-06	5.267E-03	CDC25B, CDK1, CDK4
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	9.195E-06	6.067E-03	CA2, CA4, CA9, SLCO1B1, SLCO1B3
BP	GO:0009987; cellular process	GO:0010389; regulation of G2/M transition of mitotic cell cycle	1.245E-05	7.972E-03	AURKA, AURKB, CDK1, CDK2, CDK4
BP	GO:0051179; localization	GO:0015721; bile acid and bile salt transport	1.334E-05	8.218E-03	NR1H4, SLCO1B1, SLCO1B3
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.396E-05	8.218E-03	PTPN1, PTPN2
MF	GO:0005488; binding	GO:0030332; cyclin binding	1.476E-05	8.456E-03	CDK1, CDK2, CDK4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.166E-22	1.269E-18	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.749E-21	1.633E-17	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004693; cyclin-dependent protein serine/threonine kinase activity	2.140E-05	1.165E-02	CDK1, CDK2, CDK4
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	2.325E-05	1.192E-02	AURKA, AURKB
CC	GO:0044464; cell part	GO:0000307; cyclin-dependent protein kinase holoenzyme complex	3.463E-05	1.548E-02	CDK1, CDK2, CDK4
CC	GO:0043226; organelle	GO:0015030; Cajal body	7.097E-05	2.711E-02	CDK2, SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.314E-28	7.887E-27	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.498E-08	1.949E-06	SLCO1B1, CA2, SLCO1B3, NR1H4, CYP3A4
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	3.405E-05	6.809E-04	CDK4, CDK2, CDK1, CDC25B
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	2.384E-04	2.860E-03	POLB, CDK4, CDK2, CDK1
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	1.493E-04	2.239E-03	CDK4, CDK2, CDK1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4.208E-04	4.208E-03	CDK2, CDK1, CDC25B
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	8.163E-04	5.741E-03	CDK2, CDK1, AURKA
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.396E-04	4.625E-03	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.611E-04	5.741E-03	PLA2G1B, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	7.352E-03	4.411E-02	CDK4, CDK2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thymoma	C37, D15.0	CDK2;
C00-D49: Neoplasms	Breast cancer	C50	CDK1;
C00-D49: Neoplasms	Cancer	C00-C96	CDK2; CDK1; CDC25B;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CDK2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	CDK2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	Edema	NA	CA2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
C00-D49: Neoplasms	Solid tumours	C00-D48	CDK2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases