CMAUP Plant Collective Molecular Activities

Plant Name: Tylophora atrofolliculata

Taxonomic Information:

Plant ID: NPO18435
Plant Latin Name: Tylophora atrofolliculata
Taxonomy Genus: Tylophora
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Enzyme_unclassified	PTGES; ALOX12; HSD11B1;
Transcription Factor	JUN;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	PTGES	Prostaglandin E synthase	O14684	CHEMBL5658
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Transcription Factor	JUN	Proto-oncogene c-JUN	P05412	CHEMBL4977
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	1.145E-06	8.312E-03	ALOX12, CYP2C9, PTGES
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	9.002E-07	8.312E-03	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.250E-06	1.225E-02	CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	9.886E-06	2.153E-02	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	9.886E-06	2.153E-02	CYP2C9, CYP3A4
BP	GO:0002376; immune system process	GO:0001774; microglial cell activation	2.035E-05	4.028E-02	JUN, MAPT
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.030E-05	5.075E-02	ALOX12, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	5.643E-05	7.228E-02	MAPT, PTPN1
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	8.365E-05	8.674E-02	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.473E-04	1.283E-01	CYP2C9, CYP3A4
CC	GO:0044464; cell part	GO:0097443; sorting endosome	2.483E-03	4.660E-01	PTPN1
CC	GO:0044464; cell part	GO:0005641; nuclear envelope lumen	3.309E-03	5.337E-01	PTGES

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.571E-06	6.353E-05	CYP2C9, ALOX12, PTGES
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.579E-06	6.353E-05	HSD11B1, CYP2C9, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.665E-06	6.353E-05	HSD11B1, CYP2C9, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.329E-05	5.628E-04	HSD11B1, CYP2C9, ALOX12, CYP3A4, PTGES
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.654E-05	5.880E-04	CYP2C9, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.876E-04	2.107E-03	CYP2C9, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.289E-04	1.983E-03	HSD11B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.241E-04	2.107E-03	CYP2C9, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	8.513E-04	4.919E-03	CYP2C9, ALOX12
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	4.310E-03	2.241E-02	JUN, MAPT

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1;
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	JUN;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases