Plant Name: Ficus microcarpa
Taxonomic Information:
Plant ID: NPO18418
Plant Latin Name: Ficus microcarpa
Taxonomy Genus: Ficus
Taxonomy Family: Moraceae
Plant External Links:
NCBI TaxonomyDB:
66385
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Guinea; Philippines; Indonesia; India; Malaysia; Vietnam; China; ThailandTraditional Medicine System:
Indian Folk; TCM; Ayurveda; SiddhaGeographical Distribution:
Guinea; Philippines; Indonesia; India; Malaysia; Vietnam; China; Thailand
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ALPL; RECQL; HSD17B10; AKR1B1; | |
| GAA; | |
| NFKB1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0009636; response to toxic substance | 1.708E-04 | 5.483E-01 | AKR1B1, ALPL, NFKB1 |
| BP | GO:0009987; cellular process | GO:0031098; stress-activated protein kinase signaling cascade | 3.927E-04 | 5.483E-01 | AKR1B1, NFKB1 |
| MF | GO:0003824; catalytic activity | GO:0004574; oligo-1,6-glucosidase activity | 6.212E-04 | 5.483E-01 | GAA |
| MF | GO:0003824; catalytic activity | GO:0032450; maltose alpha-glucosidase activity | 9.316E-04 | 5.483E-01 | GAA |
| MF | GO:0003824; catalytic activity | GO:0004558; alpha-1,4-glucosidase activity | 1.242E-03 | 6.439E-01 | GAA |
| MF | GO:0003824; catalytic activity | GO:0009378; four-way junction helicase activity | 1.552E-03 | 6.898E-01 | RECQL |
| CC | GO:0032991; macromolecular complex | GO:0033256; I-kappaB/NF-kappaB complex | 2.173E-03 | 7.278E-01 | NFKB1 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 2.896E-03 | 7.598E-01 | AKR1B1, GAA |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 3.250E-05 | 2.015E-03 | GAA, AKR1B1 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.988E-04 | 6.161E-03 | GAA, AKR1B1, ALPL, HSD17B10 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 1.934E-02 | 5.455E-02 | NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 1.698E-02 | 5.455E-02 | NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 1.964E-02 | 5.455E-02 | NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.023E-02 | 5.455E-02 | NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 1.905E-02 | 5.455E-02 | NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 2.141E-02 | 5.455E-02 | NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 2.170E-02 | 5.455E-02 | NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 1.934E-02 | 5.455E-02 | NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
