CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family C GPCR)	GABBR1;
Enzyme_unclassified	BLM;
GABA-A receptor	GABRR1;
Lyase	CA12; CA9;
Methyl-lysine/arginine binding protein	KDM4C; KDM4A;
Plant homeodomain	KMT2A;
SLC superfamily of solute carriers	SLC6A1; SLC6A11;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Methyl-lysine/arginine binding protein	KDM4C	Lysine-specific demethylase 4C	Q9H3R0	CHEMBL6175
Methyl-lysine/arginine binding protein	KDM4A	Lysine-specific demethylase 4A	O75164	CHEMBL5896
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
SLC superfamily of solute carriers	SLC6A1	GABA transporter 1	P30531	CHEMBL1903
SLC superfamily of solute carriers	SLC6A11	GABA transporter 3	P48066	CHEMBL5208
Small molecule receptor (family C GPCR)	GABBR1	GABA-B receptor 1	Q9UBS5	CHEMBL2064

Showing 1 to 10 of 11 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:1900113; negative regulation of histone H3-K9 trimethylation	2.946E-06	1.545E-02	KDM4A, KDM4C
BP	GO:0051179; localization	GO:0006820; anion transport	7.046E-06	2.402E-02	CA12, CA9, GABRR1, SLC6A1, SLC6A11
BP	GO:0051179; localization	GO:0015812; gamma-aminobutyric acid transport	8.240E-06	2.402E-02	SLC6A1, SLC6A11
BP	GO:0008152; metabolic process	GO:0070544; histone H3-K36 demethylation	1.323E-05	2.402E-02	KDM4A, KDM4C
BP	GO:0008152; metabolic process	GO:0033169; histone H3-K9 demethylation	3.083E-05	3.949E-02	KDM4A, KDM4C
MF	GO:0005215; transporter activity	GO:0005332; gamma-aminobutyric acid:sodium symporter activity	1.768E-06	1.545E-02	SLC6A1, SLC6A11
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.103E-06	1.545E-02	BLM, CA12, CA9, KDM4A, KDM4C, KMT2A
MF	GO:0003824; catalytic activity	GO:0051864; histone demethylase activity (H3-K36 specific)	1.323E-05	2.402E-02	KDM4A, KDM4C
MF	GO:0003824; catalytic activity	GO:0032454; histone demethylase activity (H3-K9 specific)	2.673E-05	3.880E-02	KDM4A, KDM4C

Showing 1 to 9 of 9 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.723E-05	3.165E-04	CA12, CA9
09100 Metabolism	09105 Amino acid metabolism	hsa00310	Lysine degradation	2.824E-02	6.114E-02	KMT2A
09120 Genetic Information Processing	09124 Replication and repair	hsa03440	Homologous recombination	1.584E-02	5.385E-02	BLM
09120 Genetic Information Processing	09124 Replication and repair	hsa03460	Fanconi anemia pathway	2.877E-02	6.114E-02	BLM
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9.680E-03	4.114E-02	GABBR1, GABRR1
09150 Organismal Systems	09156 Nervous system	hsa04727	GABAergic synapse	1.128E-07	1.917E-06	GABBR1, GABRR1, SLC6A11, SLC6A1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	5.314E-02	6.579E-02	GABBR1
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	5.418E-02	6.579E-02	GABRR1
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	1.097E-03	6.214E-03	GABBR1, GABRR1
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	2.179E-02	6.114E-02	GABRR1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;

Showing 1 to 6 of 6 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Eucalyptus ovata

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities