CMAUP Plant Collective Molecular Activities

Plant Name: Papaver commutatum

Taxonomic Information:

Plant ID: NPO18366
Plant Latin Name: Papaver commutatum
Taxonomy Genus: Papaver
Taxonomy Family: Papaveraceae

Plant External Links:

NCBI TaxonomyDB: 357467
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	MTOR;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	TP53;
SLC superfamily of solute carriers	SLC22A2;
Unclassified	THPO; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP1A2; CYP3A4; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
SLC superfamily of solute carriers	SLC22A2	Solute carrier family 22 member 2	O15244	CHEMBL1743122
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.280E-12	2.786E-08	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.214E-11	4.588E-07	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	7.325E-10	3.987E-06	CYP1A2, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.255E-08	5.464E-05	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.193E-08	6.821E-05	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	4.017E-08	1.093E-04	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.417E-07	5.220E-04	CYP1A2, CYP2C19, CYP2C9, CYP3A4, NR1H4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.421E-07	5.220E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	5.492E-07	8.542E-04	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	8.739E-07	1.189E-03	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.084E-06	1.389E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.131E-06	2.320E-03	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	7.417E-06	7.022E-03	CYP1A2, CYP3A4
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	2.327E-05	1.949E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.749E-05	2.138E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	5.383E-05	3.256E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.750E-09	1.190E-07	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.289E-08	2.138E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.267E-07	2.872E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.059E-06	1.200E-04	CYP2C9, CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.002E-05	1.363E-04	CYP2C9, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	6.722E-04	5.395E-03	TP53, MTOR
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	6.117E-04	5.395E-03	CYP2C9, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.354E-04	5.395E-03	CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	7.140E-04	5.395E-03	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.255E-03	7.761E-03	TP53, MTOR
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.399E-03	7.927E-03	TP53, MTOR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	8.014E-04	5.450E-03	NR1H4, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	1.612E-03	8.435E-03	SLC22A2, MTOR
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.978E-03	9.605E-03	CYP2C9, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.192E-03	9.936E-03	TP53, MTOR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases