CMAUP Plant Collective Molecular Activities

Plant Name: Ligustrum lucidum

Taxonomic Information:

Plant ID: NPO18340
Plant Latin Name: Ligustrum lucidum
Taxonomy Genus: Ligustrum
Taxonomy Family: Oleaceae

Plant External Links:

NCBI TaxonomyDB: 458695
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

Indian Folk; TCM

Medicinal Functions:

Anodyne; Antiseptic; Antitumor; Cardiotonic; Diaphoretic; Diuretic; Febrifuge; Miscellany; Ophthalmic; Pectoral; Tonic; Vulnerary

Geographical Distribution:

India; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Peptide receptor (family A GPCR)	NPSR1;
Hydrolase	ACHE;
Enzyme_unclassified	RECQL; AKR1B10; ALOX12; HSD17B1; HSD17B10; NOX4; ALOX15; POLB;
Protein Phosphatase	CDC25B;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB; CSNK2A1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Unclassified	LMNA; FABP3; FABP5; THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A1; CYP19A1; CYP1A2; CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.444E-08	2.290E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	6.917E-08	7.927E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.378E-07	1.250E-04	ALOX12, AURKB, AXL, CDK1, CSNK2A1, FFAR4, IGF1R, KDR, LMNA, NR1H4, PIM1
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.264E-07	2.221E-04	ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	5.929E-07	3.466E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.073E-06	4.972E-04	AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.602E-06	6.461E-04	ESR2, NR1H4, PPARA, RORC
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	2.123E-06	7.971E-04	AKR1B10, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B10, NOX4
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	3.007E-06	9.922E-04	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0020037; heme binding	2.818E-06	9.922E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	3.007E-06	9.922E-04	ALOX12, ALOX15
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	3.399E-06	1.057E-03	ESR2, NR1H4, PPARA, RORC
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	6.485E-06	1.765E-03	CYP1A1, CYP1A2, CYP1B1
MF	Unclassified;	GO:0004872; receptor activity	7.298E-06	1.899E-03	AXL, ESR2, FFAR1, FFAR4, FLT3, IGF1R, KDR, MET, NPSR1, NR1H4, PPARA, RORC
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	8.393E-06	2.125E-03	CDK1, ESR2, NR1H4, PPARA, RORC
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	8.614E-06	2.156E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	9.012E-06	2.205E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	9.012E-06	2.205E-03	ALOX12, ALOX15
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	9.382E-06	2.245E-03	AXL, CDK1, CSNK2A1, FLT3
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.296E-05	2.823E-03	ESR2, NR1H4, PIM1, PPARA, RORC
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	1.316E-05	2.829E-03	ALOX15, AXL, CDK1, CYP1A1, CYP1A2, CYP1B1, KDR
MF	GO:0005488; binding	GO:0005504; fatty acid binding	1.416E-05	2.888E-03	FABP3, FABP5, FFAR4
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	1.446E-05	2.916E-03	ACHE, ALOX15, CDK1, CYP1A1, PPARA
MF	GO:0005488; binding	GO:0005496; steroid binding	1.534E-05	3.009E-03	ESR2, HSD17B1, NR1H4, RORC
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	1.620E-05	3.149E-03	ALOX12, CDC25B, CDK1, CSNK2A1, FLT3, IGF1R, KDR, PIM1, THPO
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.740E-05	3.324E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.800E-05	3.380E-03	CYP1A1, CYP1A2
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	2.295E-05	4.050E-03	ALOX15, FFAR4, KDR, NOX4, THPO
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	2.997E-05	4.945E-03	ALOX12, ALOX15
BP	GO:0050896; response to stimulus	GO:0010243; response to organonitrogen compound	4.123E-05	6.412E-03	CDK1, FABP3, FFAR4, FLT3, IGF1R, NOX4, NR1H4, PPARA
BP	GO:0008152; metabolic process	GO:0008610; lipid biosynthetic process	4.169E-05	6.438E-03	ACHE, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1
BP	GO:0040011; locomotion	GO:0030334; regulation of cell migration	4.606E-05	6.965E-03	ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, LMNA, MET, NOX4
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	4.817E-05	7.184E-03	CYP19A1, FFAR4, NR1H4, PPARA
BP	GO:0032502; developmental process	GO:0007568; aging	4.911E-05	7.275E-03	AURKB, CDK1, CYP1A1, NOX4, POLB
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	6.281E-05	9.057E-03	FLT3, KDR
BP	GO:0008152; metabolic process	GO:0046486; glycerolipid metabolic process	6.605E-05	9.400E-03	ACHE, ALOX15, CSNK2A1, FABP3, FABP5, MET

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.095E-08	1.801E-06	HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.487E-08	1.929E-06	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.248E-05	1.218E-03	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.574E-04	3.840E-03	CYP1A2, CYP1A1, CYP1B1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.679E-04	3.840E-03	CSNK2A1, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.178E-04	3.840E-03	FABP3, FABP5, PPARA
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6.114E-04	6.573E-03	CDK1, CDC25B, IGF1R
Unclassified	Unclassified	hsa01100	Metabolic pathways	9.048E-04	8.646E-03	AKR1B10, HSD17B1, CYP1A2, ALOX15, CYP1A1, ALOX12, CYP19A1, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.627E-04	4.456E-03	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1.022E-03	8.651E-03	THPO, FLT3, KDR, MET
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.107E-03	8.651E-03	CYP1A2, ALOX15

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Melanoma	C43	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; CSNK2A1; FLT3; ACHE; CDC25B;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CYP19A1;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Glioma	C71	KDR;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases