CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR1A;
ATP-binding cassette	ABCG2;
Unclassified	F3; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 4 of 4 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	8.281E-04	1.000E+00	HTR1A
BP	GO:0009987; cellular process	GO:0014062; regulation of serotonin secretion	1.449E-03	1.000E+00	HTR1A
BP	GO:0032501; multicellular organismal process	GO:0055015; ventricular cardiac muscle cell development	2.069E-03	1.000E+00	LMNA
BP	GO:0051179; localization	GO:0042908; xenobiotic transport	2.069E-03	1.000E+00	ABCG2
BP	GO:0008152; metabolic process	GO:0046415; urate metabolic process	2.690E-03	1.000E+00	ABCG2
BP	GO:0009987; cellular process	GO:0090201; negative regulation of release of cytochrome c from mitochondria	3.516E-03	1.000E+00	LMNA
BP	GO:0008152; metabolic process	GO:0042053; regulation of dopamine metabolic process	3.929E-03	1.000E+00	HTR1A
BP	GO:0051179; localization	GO:0033344; cholesterol efflux	4.961E-03	1.000E+00	ABCG2
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	4.961E-03	1.000E+00	HTR1A
BP	GO:0050896; response to stimulus	GO:0050927; positive regulation of positive chemotaxis	5.167E-03	1.000E+00	F3

Showing 1 to 10 of 31 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	8.772E-03	2.962E-02	ABCG2
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.771E-02	3.325E-02	LMNA
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.413E-02	2.962E-02	ABCG2
09150 Organismal Systems	09157 Sensory system	hsa04742	Taste transduction	1.650E-02	2.962E-02	HTR1A
09150 Organismal Systems	09151 Immune system	hsa04610	Complement and coagulation cascades	1.571E-02	2.962E-02	F3
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.221E-02	2.962E-02	HTR1A
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.472E-02	2.962E-02	LMNA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.005E-02	2.962E-02	F3
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	1.650E-02	2.962E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.788E-02	2.962E-02	LMNA

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HTR1A;

Showing 1 to 10 of 33 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Macaranga bicolor

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities