Plant Name: Macaranga bicolor
Taxonomic Information:
Plant ID: NPO18288
Plant Latin Name: Macaranga bicolor
Taxonomy Genus: Macaranga
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
396452
Plant-of-the-World-Online:
351050-1
Used in Medicines:
Unknown.
Geographical Distribution:
Philippines
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HTR1A; | |
| ABCG2; | |
| F3; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Small molecule receptor (family A GPCR) | HTR1A | Serotonin 1a (5-HT1a) receptor | P08908 | CHEMBL214 |
| Unclassified | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway | 8.281E-04 | 1.000E+00 | HTR1A |
| BP | GO:0009987; cellular process | GO:0014062; regulation of serotonin secretion | 1.449E-03 | 1.000E+00 | HTR1A |
| BP | GO:0032501; multicellular organismal process | GO:0055015; ventricular cardiac muscle cell development | 2.069E-03 | 1.000E+00 | LMNA |
| BP | GO:0051179; localization | GO:0042908; xenobiotic transport | 2.069E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0008152; metabolic process | GO:0046415; urate metabolic process | 2.690E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0009987; cellular process | GO:0090201; negative regulation of release of cytochrome c from mitochondria | 3.516E-03 | 1.000E+00 | LMNA |
| BP | GO:0008152; metabolic process | GO:0042053; regulation of dopamine metabolic process | 3.929E-03 | 1.000E+00 | HTR1A |
| BP | GO:0051179; localization | GO:0033344; cholesterol efflux | 4.961E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0009987; cellular process | GO:0007210; serotonin receptor signaling pathway | 4.961E-03 | 1.000E+00 | HTR1A |
| BP | GO:0050896; response to stimulus | GO:0050927; positive regulation of positive chemotaxis | 5.167E-03 | 1.000E+00 | F3 |
| BP | Unclassified; | GO:0042310; vasoconstriction | 5.992E-03 | 1.000E+00 | HTR1A |
| BP | GO:0007610; behavior | GO:0001662; behavioral fear response | 6.198E-03 | 1.000E+00 | HTR1A |
| BP | GO:0009987; cellular process | GO:0007077; mitotic nuclear envelope disassembly | 9.081E-03 | 1.000E+00 | LMNA |
| BP | GO:0040011; locomotion | GO:0030334; regulation of cell migration | 9.117E-03 | 1.000E+00 | F3, LMNA |
| BP | GO:0007610; behavior | GO:0050795; regulation of behavior | 1.319E-02 | 1.000E+00 | HTR1A |
| BP | GO:0051179; localization | GO:0006855; drug transmembrane transport | 1.319E-02 | 1.000E+00 | ABCG2 |
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 1.687E-02 | 1.000E+00 | F3 |
| BP | GO:0008283; cell proliferation | GO:0001938; positive regulation of endothelial cell proliferation | 1.769E-02 | 1.000E+00 | F3 |
| BP | GO:0023052; signaling | GO:0023051; regulation of signaling | 1.929E-02 | 1.000E+00 | F3, HTR1A, LMNA |
| BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 2.116E-02 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 2.136E-02 | 1.000E+00 | LMNA |
| BP | GO:0032501; multicellular organismal process | GO:0097746; regulation of blood vessel diameter | 2.543E-02 | 1.000E+00 | HTR1A |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 3.111E-02 | 1.000E+00 | F3 |
| BP | GO:0032502; developmental process | GO:0045766; positive regulation of angiogenesis | 3.151E-02 | 1.000E+00 | F3 |
| BP | GO:0051179; localization | GO:1900180; regulation of protein localization to nucleus | 4.499E-02 | 1.000E+00 | LMNA |
| CC | GO:0044421; extracellular region part | GO:0031012; extracellular matrix | 4.092E-03 | 1.000E+00 | F3, LMNA |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 3.333E-02 | 1.000E+00 | LMNA |
| MF | GO:0005215; transporter activity | GO:0008559; xenobiotic transmembrane transporting ATPase activity | 1.449E-03 | 1.000E+00 | ABCG2 |
| MF | GO:0005488; binding | GO:0051378; serotonin binding | 2.276E-03 | 1.000E+00 | HTR1A |
| MF | GO:0060089; molecular transducer activity | GO:0004993; G-protein coupled serotonin receptor activity | 4.961E-03 | 1.000E+00 | HTR1A |
| MF | Unclassified; | GO:0004872; receptor activity | 3.482E-02 | 1.000E+00 | F3, HTR1A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 8.772E-03 | 2.962E-02 | ABCG2 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 2.962E-02 | LMNA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.413E-02 | 2.962E-02 | ABCG2 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.005E-02 | 2.962E-02 | F3 |
| 09150 Organismal Systems | 09157 Sensory system | hsa04742 | Taste transduction | 1.650E-02 | 2.962E-02 | HTR1A |
| 09150 Organismal Systems | 09151 Immune system | hsa04610 | Complement and coagulation cascades | 1.571E-02 | 2.962E-02 | F3 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.650E-02 | 2.962E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.788E-02 | 2.962E-02 | LMNA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 2.221E-02 | 2.962E-02 | HTR1A |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.771E-02 | 3.325E-02 | LMNA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| NA: NA | Episode | NA | HTR1A; |
| NA: NA | Peripheral sensory neuropathies | NA | HTR1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | HTR1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Generalized anxiety disorder | F32, F40-F42, F41.1 | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | HTR1A; |
| NA: NA | Social phobia | NA | HTR1A; |
| I00-I99: Diseases of the circulatory system | Hypertension | I10-I16 | HTR1A; |
| NA: NA | Schizoaffective disorder | NA | HTR1A; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Eating disorder | E66, F50, I10-I16, I50 | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Premature ejaculation | F52.4 | HTR1A; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Spasm | R25.2 | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | HTR1A; |
| I00-I99: Diseases of the circulatory system | Bleeding | I74, I80-I82 | F3; |
| N00-N99: Diseases of the genitourinary system | Urinary incontinence | N39.3, N39.4, R32 | HTR1A; |
| NA: NA | Bulimia nervosa | NA | HTR1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | HTR1A; |
| J00-J99: Diseases of the respiratory system | Adult respiratory distress syndrome | J80 | F3; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychiatric disorder | F01-F99 | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | HTR1A; |
| I00-I99: Diseases of the circulatory system | Coronary artery disease | I20-I25 | HTR1A; |
| NA: NA | Cervical dystonia | NA | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Hypoactive sexual desire disorder | F52.0 | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | HTR1A; |
| NA: NA | Anxiety disorders | NA | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Female sexual dysfunction | F52 | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Severe mood disorders | F30-F39 | HTR1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | HTR1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Lateral sclerosis | G12.2 | HTR1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | HTR1A; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | F3; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
