Plant Name: Spilanthes ocymifolia
Taxonomic Information:
Plant ID: NPO18214
Plant Latin Name: Spilanthes ocymifolia
Taxonomy Genus: Spilanthes
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| NR1H4; | |
| XPO1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Unclassified | XPO1 | Exportin-1 | O14980 | CHEMBL5661 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 9.052E-14 | 1.971E-09 | CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 2.789E-10 | 3.036E-06 | CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 8.948E-10 | 6.494E-06 | CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 6.403E-09 | 2.451E-05 | CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 6.403E-09 | 2.451E-05 | CYP2C9, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 6.754E-09 | 2.451E-05 | CYP2C19, CYP2C9, CYP2D6, CYP3A4, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 3.973E-08 | 8.651E-05 | CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 6.340E-08 | 1.151E-04 | CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0016705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 1.370E-07 | 2.131E-04 | CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.557E-07 | 2.260E-04 | CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 3.377E-07 | 4.595E-04 | CYP2D6, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 6.752E-07 | 8.168E-04 | CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 5.059E-06 | 4.375E-03 | CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0032787; monocarboxylic acid metabolic process | 1.232E-05 | 9.558E-03 | CYP2C19, CYP2C9, CYP2D6, NR1H4 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 1.601E-04 | 8.107E-02 | CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| CC | GO:0016020; membrane | GO:0031090; organelle membrane | 8.975E-04 | 2.355E-01 | CYP2C19, CYP2C9, CYP2D6, CYP3A4, XPO1 |
| CC | GO:0043226; organelle | GO:0015030; Cajal body | 1.870E-02 | 1.000E+00 | XPO1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 4.505E-09 | 9.460E-08 | CYP2C9, CYP2D6, CYP3A4, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 9.556E-08 | 1.003E-06 | CYP2C9, CYP3A4, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.616E-06 | 1.131E-05 | CYP2C9, CYP2D6, CYP3A4 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 5.887E-06 | 2.472E-05 | CYP2C9, CYP2D6, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 2.298E-06 | 1.206E-05 | CYP2C9, CYP3A4, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.966E-04 | 6.484E-04 | CYP2C9, CYP2C19 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.161E-04 | 6.484E-04 | CYP2C9, CYP3A4 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.580E-04 | 6.771E-04 | NR1H4, CYP3A4 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 6.873E-03 | 1.604E-02 | CYP2C9, CYP2C19, CYP3A4 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 1.841E-02 | 3.251E-02 | TSHR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
